Quantitative Evaluation of Type 1 and Type 2 Choroidal Neovascularization Components Under Treatment With Projection-Resolved OCT Angiography.

IF 5 2区医学 Q1 OPHTHALMOLOGY Investigative ophthalmology & visual science Pub Date : 2024-09-03 DOI:10.1167/iovs.65.11.32

Kotaro Tsuboi, Qi Sheng You, Jie Wang, Yukun Guo, Christina J Flaxel, Thomas S Hwang, David Huang, Yali Jia, Steven T Bailey

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Abstract

Purpose: To evaluate the response of type 1 and type 2 macular neovascularization (MNV) components under anti-vascular endothelial growth factor (VEGF) treatment in age-related macular degeneration (AMD) using projection-resolved optical coherence tomography angiography (PR-OCTA).

Methods: This retrospective study included eyes with treatment-naïve exudative AMD treated with anti-VEGF injections under a pro re nata (PRN) protocol over 1 year. Two-dimensional MNV areas and three-dimensional MNV volumes were derived from macular PR-OCTA scans using an automated convolutional neural network. MNV was detected as flow signal within the outer retinal slab. Type 1 components and type 2 components were analyzed separately.

Results: Of 17 enrolled eyes, 12 eyes were pure type 1 MNV and five eyes were type 2 MNV. In eyes with pure type 1, the total (sum of type 1 and type 2 components) MNV area and volume did not change from baseline to 6 months or 12 months (P > 0.05). In eyes with type 2 MNV, the total MNV area significantly decreased from the baseline to 6 months (P = 0.0074) and 12 months (P = 0.014). The total type 2 MNV volume also decreased from baseline visit to visits at 6 months and at 12 months, nearing statistical signifiicance (P = 0.061 and P = 0.074). In eyes with type 2 MNV, the type 1 component increased from 0.093 mm2 to 0.30 mm2 (P = 0.058), and the type 2 component decreased from 0.37 mm2 at 6 months to 0 at 12 months (P = 0.0087).

Conclusions: Type 1 and type 2 MNV may have different response under PRN anti-VEGF treatment over 1 year.

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用投影解析 OCT 血管造影定量评估治疗中的 1 型和 2 型脉络膜新生血管成分。

目的：使用投影分辨光学相干断层血管造影术（PR-OCTA）评估抗血管内皮生长因子（VEGF）治疗老年性黄斑变性（AMD）过程中 1 型和 2 型黄斑新生血管（MNV）成分的反应：这项回顾性研究纳入了接受抗血管内皮生长因子（VEGF）注射治疗一年以上、治疗无效的渗出性 AMD 患者。使用自动卷积神经网络从黄斑 PR-OCTA 扫描中得出二维 MNV 面积和三维 MNV 体积。MNV 作为视网膜外板内的流动信号被检测出来。分别分析了1型成分和2型成分：在 17 只入选眼球中，12 只为纯 1 型 MNV，5 只为 2 型 MNV。在纯1型MNV患者中，MNV总面积和体积（1型和2型成分之和）从基线到6个月或12个月没有变化（P>0.05）。在 2 型 MNV 患者中，MNV 总面积从基线到 6 个月（P = 0.0074）和 12 个月（P = 0.014）显著减少。2 型 MNV 的总体积从基线到 6 个月和 12 个月时也有所下降，接近统计学意义（P = 0.061 和 P = 0.074）。在 2 型 MNV 患者中，1 型成分从 0.093 平方毫米增加到 0.30 平方毫米（P = 0.058），2 型成分从 6 个月时的 0.37 平方毫米减少到 12 个月时的 0 平方毫米（P = 0.0087）：结论：1型和2型MNV在PRN抗血管内皮生长因子治疗1年后可能会有不同的反应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Investigative ophthalmology & visual science 医学-眼科学

CiteScore

6.90

自引率

4.50%

发文量

339

审稿时长

1 months

期刊介绍： Investigative Ophthalmology & Visual Science (IOVS), published as ready online, is a peer-reviewed academic journal of the Association for Research in Vision and Ophthalmology (ARVO). IOVS features original research, mostly pertaining to clinical and laboratory ophthalmology and vision research in general.