Lipid profile is similar in both subjects with high 1-hour postload glucose and 2-hour postload glucose and is related to cardio-metabolic profile in prediabetes

IF 2.9 3区医学 Q3 ENDOCRINOLOGY & METABOLISM Journal of diabetes and its complications Pub Date : 2024-09-18 DOI:10.1016/j.jdiacomp.2024.108869

Rumyana Dimova, Nevena Chakarova, Mina Serdarova, Tsvetalina Tankova

{"title":"Lipid profile is similar in both subjects with high 1-hour postload glucose and 2-hour postload glucose and is related to cardio-metabolic profile in prediabetes","authors":"Rumyana Dimova, Nevena Chakarova, Mina Serdarova, Tsvetalina Tankova","doi":"10.1016/j.jdiacomp.2024.108869","DOIUrl":null,"url":null,"abstract":"<div><h3>Aim</h3><div>The study aimed to investigate a lipid profile in people with normal glucose tolerance (NGT), NGT and 1hrOGTT > 8.6 mmol/l, and impaired glucose tolerance (IGT); and to assess its association with some cardio-metabolic parameters.</div></div><div><h3>Material and methods</h3><div>A total of 90 subjects, of mean age 46.7 ± 10.5 years and mean BMI of 32.0 ± 6.3 kg/m<sup>2</sup> were enrolled. They were divided into 3 groups: 19 with NGT, 22 with NGT and 1hrOGTT > 8.6 mmol/l, and 49 with IGT; and subdivided into 2 subgroups according to HOMA-IR: 40 with HOMA-IR < 2.5 and 50 with HOMA-IR ≥ 2.5. Body composition (Inbody 720) and advanced glycation end products (AGE Reader) were assessed. Two functional tests (OGTT; MMTT) were performed and AUC for glucose, insulin and triglycerides were calculated.</div></div><div><h3>Results</h3><div>There was no difference across the glucose tolerance groups for all evaluated lipids. The results showed higher AUC<sub>insulin</sub> during OGTT (<em>p</em> = 0.037 and 0.020), AUC<sub>triglycerides</sub> during MMTT (<em>p</em> = 0.048) and triglycerides/HDL ratio (<em>p</em> = 0.064 and 0.016) in the 1hrOGTT and IGT subgroups with HOMA-IR ≥ 2.5 in comparison to those with HOMA-IR < 2.5. AUC<sub>triglycerides</sub> during OGTT is independently related to body composition, b-cell function and insulin sensitivity; and AUC<sub>triglycerides</sub> during MMTT is independently related to blood pressure and hsCRP in prediabetes. Triglycerides/HDL-C ratio emerged as an independent contributor to glycaemia and insulinemia.</div></div><div><h3>Conclusion</h3><div>Our results demonstrate a similar lipid profile in subjects with 1hrOGTT > 8.6 mmol/l and IGT, whereas increased AUC<sub>triglycerides</sub> during OGTT, AUC<sub>triglycerides</sub> during MMTT and triglycerides/HDL-C ratio have been found in the subgroups with insulin resistance. The triglycerides/HDL-C ratio outlined as an independent predictor of insulin secretion and action, and postload triglycerides appear to be independently related to most of the metabolic parameters.</div></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"38 11","pages":"Article 108869"},"PeriodicalIF":2.9000,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1056872724001958/pdfft?md5=ea5ab3c3aff11eaa8f9916b47a5ef7fb&pid=1-s2.0-S1056872724001958-main.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of diabetes and its complications","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1056872724001958","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}

引用次数: 0

Abstract

Aim

The study aimed to investigate a lipid profile in people with normal glucose tolerance (NGT), NGT and 1hrOGTT > 8.6 mmol/l, and impaired glucose tolerance (IGT); and to assess its association with some cardio-metabolic parameters.

Material and methods

A total of 90 subjects, of mean age 46.7 ± 10.5 years and mean BMI of 32.0 ± 6.3 kg/m² were enrolled. They were divided into 3 groups: 19 with NGT, 22 with NGT and 1hrOGTT > 8.6 mmol/l, and 49 with IGT; and subdivided into 2 subgroups according to HOMA-IR: 40 with HOMA-IR < 2.5 and 50 with HOMA-IR ≥ 2.5. Body composition (Inbody 720) and advanced glycation end products (AGE Reader) were assessed. Two functional tests (OGTT; MMTT) were performed and AUC for glucose, insulin and triglycerides were calculated.

Results

There was no difference across the glucose tolerance groups for all evaluated lipids. The results showed higher AUC_insulin during OGTT (p = 0.037 and 0.020), AUC_{triglycerides} during MMTT (p = 0.048) and triglycerides/HDL ratio (p = 0.064 and 0.016) in the 1hrOGTT and IGT subgroups with HOMA-IR ≥ 2.5 in comparison to those with HOMA-IR < 2.5. AUC_{triglycerides} during OGTT is independently related to body composition, b-cell function and insulin sensitivity; and AUC_{triglycerides} during MMTT is independently related to blood pressure and hsCRP in prediabetes. Triglycerides/HDL-C ratio emerged as an independent contributor to glycaemia and insulinemia.

Conclusion

Our results demonstrate a similar lipid profile in subjects with 1hrOGTT > 8.6 mmol/l and IGT, whereas increased AUC_{triglycerides} during OGTT, AUC_{triglycerides} during MMTT and triglycerides/HDL-C ratio have been found in the subgroups with insulin resistance. The triglycerides/HDL-C ratio outlined as an independent predictor of insulin secretion and action, and postload triglycerides appear to be independently related to most of the metabolic parameters.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

负荷后 1 小时血糖高和负荷后 2 小时血糖高的受试者的血脂状况相似，并且与糖尿病前期的心血管代谢状况有关。

目的：该研究旨在调查正常糖耐量（NGT）、NGT 和 1hrOGTT > 8.6 mmol/l 以及糖耐量受损（IGT）人群的血脂状况，并评估其与一些心血管代谢参数的关系：共招募了 90 名受试者，平均年龄为 46.7 ± 10.5 岁，平均体重指数为 32.0 ± 6.3 kg/m2。他们被分为 3 组：19 人患有 NGT，22 人患有 NGT 且 1hrOGTT > 8.6 mmol/l，49 人患有 IGT；根据 HOMA-IR 再分为 2 个亚组：40 人患有 HOMA-IR 结果：各糖耐量组的血脂评估结果均无差异。结果显示，与 HOMA-IR ≥ 2.5 的 1hrOGTT 和 IGT 亚组相比，HOMA-IR ≥ 2.5 的 1hrOGTT 和 IGT 亚组在 OGTT 期间的胰岛素 AUC（p = 0.037 和 0.020）、MMTT 期间的甘油三酯 AUC（p = 0.048）和甘油三酯/高密度脂蛋白比率（p = 0.064 和 0.016）更高。与 HOMA-IR ≥ 2.5 的亚组相比，OGTT 期间的甘油三酯与身体组成、b 细胞功能和胰岛素敏感性独立相关；MMTT 期间的甘油三酯 AUC 与糖尿病前期的血压和 hsCRP 独立相关。甘油三酯/高密度脂蛋白胆固醇比率是导致血糖和胰岛素血症的独立因素：我们的研究结果表明，1hrOGTT > 8.6 mmol/l 和 IGT 受试者的血脂状况相似，而在胰岛素抵抗亚组中，OGTT 期间的 AUCtriglycerides、MMTT 期间的 AUCtriglycerides 和甘油三酯/HDL-C 比率均有所增加。甘油三酯/HDL-C比率是胰岛素分泌和作用的独立预测指标，负荷后甘油三酯似乎与大多数代谢参数都有独立的关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Journal of diabetes and its complications 医学-内分泌学与代谢

CiteScore

5.90

自引率

3.30%

发文量

153

审稿时长

16 days

期刊介绍： Journal of Diabetes and Its Complications (JDC) is a journal for health care practitioners and researchers, that publishes original research about the pathogenesis, diagnosis and management of diabetes mellitus and its complications. JDC also publishes articles on physiological and molecular aspects of glucose homeostasis. The primary purpose of JDC is to act as a source of information usable by diabetes practitioners and researchers to increase their knowledge about mechanisms of diabetes and complications development, and promote better management of people with diabetes who are at risk for those complications. Manuscripts submitted to JDC can report any aspect of basic, translational or clinical research as well as epidemiology. Topics can range broadly from early prediabetes to late-stage complicated diabetes. Topics relevant to basic/translational reports include pancreatic islet dysfunction and insulin resistance, altered adipose tissue function in diabetes, altered neuronal control of glucose homeostasis and mechanisms of drug action. Topics relevant to diabetic complications include diabetic retinopathy, neuropathy and nephropathy; peripheral vascular disease and coronary heart disease; gastrointestinal disorders, renal failure and impotence; and hypertension and hyperlipidemia.