The effective dose of butorphanol tartrate in patients of different ages undergoing painless gastroscopy.

IF 1.5 4区医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL Journal of International Medical Research Pub Date : 2024-09-01 DOI:10.1177/03000605241277689

Yaorui Sun, Shujiao Liu, Wenli Si, Quanyi Zhang, Fei Yu, Ming Su, Chao Sun

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Abstract

Objective: This study evaluated the 50% effective dose (ED₅₀) and 95% effective dose (ED₉₅) of butorphanol tartrate in patients undergoing painless gastroscopy.

Methods: Patients who underwent painless gastroscopy at Binzhou Medical University Hospital were divided into the youth, middle-aged, and older groups. The ED₅₀ and ED₉₅ required for successful sedation using butorphanol tartrate were measured using the Dixon up-and-down method in patients in the different age groups. Patients in each group were administered intravenous butorphanol 5 minutes before gastroscopy. Each patient was administered 2 mg/kg propofol. The ED₅₀ and ED₉₅ of butorphanol were calculated using probit analysis.

Results: In total, 95 patients were included. The ED₅₀s of butorphanol in the youth, middle-aged, and older groups were 7.384, 6.657, and 6.364 μg/kg, respectively. The ED₉₅s of butorphanol doses in these groups were 9.108, 8.419, and 7.348 μg/kg, respectively.

Conclusions: The ED₅₀ and ED₉₅ varied among the age groups, indicating that the effective dose decreases with age.

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酒石酸丁吗啡诺在不同年龄段无痛胃镜检查患者中的有效剂量。

研究目的本研究评估了酒石酸丁吗啡的50%有效剂量（ED50）和95%有效剂量（ED95）在无痛胃镜检查患者中的应用情况：方法：将在滨州医科大学附属医院接受无痛胃镜检查的患者分为青年组、中年组和老年组。采用迪克森上下法测定不同年龄组患者使用酒石酸丁羟吗啡镇静所需的 ED50 和 ED95。每组患者在胃镜检查前 5 分钟静脉注射丁吗啡诺。每名患者使用 2 毫克/千克丙泊酚。采用 probit 分析法计算丁吗啡醇的 ED50 和 ED95：结果：共纳入 95 名患者。青年组、中年组和老年组的丁羟吗啡 ED50 分别为 7.384、6.657 和 6.364 μg/kg。这些组别的丁吗啡剂量 ED95 分别为 9.108、8.419 和 7.348 μg/kg：结论：不同年龄组的 ED50 和 ED95 各不相同，表明有效剂量随年龄的增长而降低。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of International Medical Research 医学-药学

CiteScore

3.20

自引率

0.00%

发文量

555

审稿时长

1 months

期刊介绍： _Journal of International Medical Research_ is a leading international journal for rapid publication of original medical, pre-clinical and clinical research, reviews, preliminary and pilot studies on a page charge basis. As a service to authors, every article accepted by peer review will be given a full technical edit to make papers as accessible and readable to the international medical community as rapidly as possible. Once the technical edit queries have been answered to the satisfaction of the journal, the paper will be published and made available freely to everyone under a creative commons licence. Symposium proceedings, summaries of presentations or collections of medical, pre-clinical or clinical data on a specific topic are welcome for publication as supplements. Print ISSN: 0300-0605