Retention in Care Among People Living with HIV in Nigeria: A Systematic Review and Meta-analysis.

IF 1.4 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Journal of research in health sciences Pub Date : 2024-08-01 Epub Date: 2024-07-31 DOI:10.34172/jrhs.2024.153
John O Olawepo, Katherine O'Brien, Julia Papasodoro, Philip E Coombs, Neha Singh, Shubhi Gupta, Aarushi Bhan, Babayemi O Olakunde, Echezona E Ezeanolue
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Abstract

Background: In 2021, Nigeria had an estimated 1.9 million people living with the human immunodeficiency virus (PLHIV) and 1.7 million (90%) on antiretroviral therapy (ART). Study Design: A systematic review and meta-analysis.

Methods: This meta-analysis followed the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) 2020 guidelines. We searched PubMed, Embase, PsychINFO, CINAHL, Global Index Medicus, and Cochrane Library. Studies were included if they reported on ART retention in care among PLHIV in Nigeria. The random-effects meta-analyses were used to combine the studies that had complete retention data. The I2 statistic was used to assess the heterogeneity of the studies. A sensitivity analysis was then done by conducting a leave-one-out analysis. Afterward, data were analyzed using STATA version 18.

Results: The search yielded 966 unique articles, of which 52 studies met the inclusion criteria for the meta-analysis, and four experimental studies were split into their component arms. The total number of study participants was 563,410, and the pooled retention rate was 72% (95% CI: 67%, 76%; I2=99.9%; n=57). Sub-analysis showed that the Southeast region of Nigeria had the highest retention of 86% (95% CI: 78%, 92%), and the South-South had the lowest retention (58%; 95% CI: 38%, 79%).

Conclusion: In Nigeria, the pooled ART retention rate is less than optimal to achieve the UNAIDS goal of 95%, thus developing new models for ART retention is needed.

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尼日利亚艾滋病病毒感染者继续接受护理的情况:系统回顾与元分析》。
背景:2021 年,尼日利亚估计有 190 万人类免疫缺陷病毒感染者(PLHIV),其中 170 万人(90%)接受了抗逆转录病毒疗法(ART)。研究设计:系统回顾和荟萃分析:本荟萃分析遵循《系统综述和荟萃分析首选报告项目》(PRISMA)2020 指南。我们检索了 PubMed、Embase、PsychINFO、CINAHL、Global Index Medicus 和 Cochrane Library。如果研究报告了尼日利亚 PLHIV 接受抗逆转录病毒疗法治疗的情况,则将其纳入研究范围。随机效应荟萃分析用于合并具有完整保留率数据的研究。I2统计量用于评估研究的异质性。然后,通过进行撇除分析进行了敏感性分析。之后,使用 STATA 18 版本对数据进行分析:搜索结果显示,共有 966 篇文章符合荟萃分析的纳入标准,其中有 52 项研究符合荟萃分析的纳入标准,有 4 项实验研究被分为不同的研究臂。研究参与者总数为 563 410 人,汇总保留率为 72%(95% CI:67%,76%;I2=99.9%;n=57)。子分析显示,尼日利亚东南部地区的保留率最高,为86%(95% CI:78%,92%),而南部-南部地区的保留率最低(58%;95% CI:38%,79%):在尼日利亚,抗逆转录病毒疗法的总体保留率低于实现联合国艾滋病规划署 95% 目标的最佳水平,因此需要开发新的抗逆转录病毒疗法保留率模式。
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来源期刊
Journal of research in health sciences
Journal of research in health sciences PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-
CiteScore
2.30
自引率
13.30%
发文量
7
期刊介绍: The Journal of Research in Health Sciences (JRHS) is the official journal of the School of Public Health; Hamadan University of Medical Sciences, which is published quarterly. Since 2017, JRHS is published electronically. JRHS is a peer-reviewed, scientific publication which is produced quarterly and is a multidisciplinary journal in the field of public health, publishing contributions from Epidemiology, Biostatistics, Public Health, Occupational Health, Environmental Health, Health Education, and Preventive and Social Medicine. We do not publish clinical trials, nursing studies, animal studies, qualitative studies, nutritional studies, health insurance, and hospital management. In addition, we do not publish the results of laboratory and chemical studies in the field of ergonomics, occupational health, and environmental health
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