Incidence and clinical course of chronic thromboembolic pulmonary hypertension with or without a history of venous thromboembolism in Denmark.

IF 5.5 2区 医学 Q1 HEMATOLOGY Journal of Thrombosis and Haemostasis Pub Date : 2024-09-19 DOI:10.1016/j.jtha.2024.09.006
Frederikus A Klok, Emese Vágó, Erzsébet Horváth-Puhó, Stefano Barco, Asger Andersen, Kasper Bonnesen, Anton Vonk-Noordegraaf, Marion Delcroix, Stavros V Konstantinides, Dieuwke Luijten, Suzanne C Cannegieter, Henrik Toft Sørensen
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引用次数: 0

Abstract

Background: A considerable number of patients with chronic thromboembolic pulmonary hypertension (CTEPH) lack a history of venous thromboembolism (VTE).

Objectives: We aimed to examine the annual incidence and prevalence of CTEPH in Denmark and to compare the rates of VTE, bleeding, and mortality between CTEPH patients with and without a history of VTE.

Methods: The Danish National Patient Registry covering all Danish hospitals was used to identify all CTEPH cases between 2009 and 2018, based on combinations of discharge diagnoses using International Classification of Diseases, 10th Revision codes for CTEPH and relevant diagnostic and/or therapeutic interventions. Incidence rates of CTEPH per 100 000 person-years, rates of VTE and bleeding, and 5-year survival estimates were calculated.

Results: In total, 509 CTEPH patients were identified, of whom 82% had a history of VTE. The yearly incidence rate of CTEPH was 0.5 to 0.8 per 100 000 person-years during the study period. Patients with a history of VTE experienced a 2.5-fold rate of VTE compared with those without prior VTE (2571 vs 980 per 100 000 person-years), while the rate of bleeding events was lower (5008 vs 7139 per 100 000 person-years). The 5-year survival of CTEPH patients with a VTE history was 65% (95% CI, 58%-71%) compared with 45% (95% CI, 31%-58%) in patients without a history of VTE.

Conclusion: The Danish incidence rate of CTEPH was comparable with that of other European countries. We identified notable differences in the prognosis of patients with CTEPH with or without a history of VTE. These findings may support generation of hypotheses regarding the pathophysiology of CTEPH and inform current patient care.

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丹麦有静脉血栓栓塞史或无静脉血栓栓塞史的慢性血栓栓塞性肺动脉高压的发病率和临床过程。
导言:相当多的慢性血栓栓塞性肺动脉高压(CTEPH)患者没有静脉血栓栓塞症(VTE)病史。我们研究了丹麦 CTEPH 的年发病率和患病率,并比较了有 VTE 病史和无 VTE 病史的 CTEPH 患者的 VTE 发生率、出血率和死亡率:利用覆盖丹麦所有医院的丹麦国家患者登记处,根据使用ICD-10代码的CTEPH出院诊断和相关诊断和/或治疗干预的组合,确定2009年至2018年期间的所有CTEPH病例。计算了每10万人年的CTEPH发病率、VTE和出血率以及5年生存率:结果:共发现 509 名 CTEPH 患者,其中 82% 有 VTE 病史。在研究期间,CTEPH的年发病率为0.5-0.8/100,000人年。与无 VTE 病史的患者相比,有 VTE 病史的患者的 VTE 发生率是无 VTE 患者的 2.5 倍(2571 对 980/100,000/人-年),而出血事件的发生率较低(分别为 5008 对 7139/100,000/人-年)。有 VTE 病史的 CTEPH 患者的 5 年生存率为 65%(95% 置信区间 (CI) 58-71),而无 VTE 病史的患者的 5 年生存率为 45%(95% 置信区间 (CI) 31-58):结论:丹麦的 CTEPH 发病率与其他欧洲国家相当。我们发现,有无 VTE 病史的 CTEPH 患者的预后存在明显差异。这些发现有助于提出 CTEPH 的病理生理学假设,并为当前的患者护理提供参考。
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来源期刊
Journal of Thrombosis and Haemostasis
Journal of Thrombosis and Haemostasis 医学-外周血管病
CiteScore
24.30
自引率
3.80%
发文量
321
审稿时长
1 months
期刊介绍: The Journal of Thrombosis and Haemostasis (JTH) serves as the official journal of the International Society on Thrombosis and Haemostasis. It is dedicated to advancing science related to thrombosis, bleeding disorders, and vascular biology through the dissemination and exchange of information and ideas within the global research community. Types of Publications: The journal publishes a variety of content, including: Original research reports State-of-the-art reviews Brief reports Case reports Invited commentaries on publications in the Journal Forum articles Correspondence Announcements Scope of Contributions: Editors invite contributions from both fundamental and clinical domains. These include: Basic manuscripts on blood coagulation and fibrinolysis Studies on proteins and reactions related to thrombosis and haemostasis Research on blood platelets and their interactions with other biological systems, such as the vessel wall, blood cells, and invading organisms Clinical manuscripts covering various topics including venous thrombosis, arterial disease, hemophilia, bleeding disorders, and platelet diseases Clinical manuscripts may encompass etiology, diagnostics, prognosis, prevention, and treatment strategies.
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