Pharmacokinetics and Plasma Protein Binding of Flunixin in Rainbow Trout (Oncorhynchus mykiss).

IF 1.5 4区 农林科学 Q3 PHARMACOLOGY & PHARMACY Journal of veterinary pharmacology and therapeutics Pub Date : 2024-09-15 DOI:10.1111/jvp.13481
Kamil Uney, Orhan Corum, Duygu Durna Corum, Devran Coskun, Fatih Sakin, Muammer Elmas
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Abstract

Flunixin's pharmacokinetics, bioavailability, and plasma protein binding were examined in rainbow trout. The experiment involved 252 rainbow trout (Oncorhynchus mykiss) maintained at 12 ± 0.6°C. Flunixin was administered to rainbow trout via intravascular (IV), intramuscular (IM), and oral routes at a dosage of 2.2 mg/kg. Plasma samples were collected at times 0 (control), 0.25, 0.5, 1, 2, 4, 6, 8, 10, 12, 24, 48, 72, and 96 h. High-pressure liquid chromatography-ultraviolet was employed to quantify flunixin concentrations. The elimination half-life (t1/2ʎz) for flunixin was 8.37 h for IV, 8.68 h for IM, and 8.76 h for oral. The t1/2ʎz was similar between administration groups. The volume of distribution at a steady state and total body clearance were 55.81 mL/kg and 6.83 mL/h/kg, respectively, after IV administration. The mean peak plasma concentration was 6.24 ± 0.41 μg/mL at 4 h for oral administration and 13.98 ± 0.86 μg/mL at 2 h for IM administration. The in vitro protein binding ratio of flunixin in rainbow trout plasma was 96.34 ± 2.29%. The bioavailability of flunixin after oral (25.74%) administration was lower than that after IM (66.70%) administration. Thus, developing an oral pharmaceutical formulation that can be administered with feed and has high bioavailability could enhance the therapeutic effect.

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虹鳟鱼(Oncorhynchus mykiss)体内氟尼辛的药代动力学和血浆蛋白结合。
研究了氟尼辛在虹鳟鱼体内的药代动力学、生物利用度和血浆蛋白结合率。实验涉及 252 条虹鳟鱼(Oncorhynchus mykiss),温度保持在 12 ± 0.6°C。虹鳟鱼通过血管内(IV)、肌肉注射(IM)和口服途径服用氟尼辛,剂量为 2.2 mg/kg。在 0(对照组)、0.25、0.5、1、2、4、6、8、10、12、24、48、72 和 96 h 采集血浆样本。静脉注射氟尼辛的消除半衰期(t1/2ʎz)为 8.37 小时,IM 为 8.68 小时,口服为 8.76 小时。给药组之间的 t1/2ʎz相似。静脉注射后,稳态分布容积和体内总清除率分别为 55.81 mL/kg 和 6.83 mL/h/kg。口服给药 4 小时后的平均血浆峰值浓度为 6.24 ± 0.41 μg/mL,IM 给药 2 小时后的平均血浆峰值浓度为 13.98 ± 0.86 μg/mL。氟尼辛在虹鳟血浆中的体外蛋白结合率为 96.34 ± 2.29%。氟尼辛口服后的生物利用度(25.74%)低于给药后的生物利用度(66.70%)。因此,开发一种可随饲料给药且生物利用度高的口服药物制剂可提高治疗效果。
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来源期刊
CiteScore
3.10
自引率
15.40%
发文量
69
审稿时长
8-16 weeks
期刊介绍: The Journal of Veterinary Pharmacology and Therapeutics (JVPT) is an international journal devoted to the publication of scientific papers in the basic and clinical aspects of veterinary pharmacology and toxicology, whether the study is in vitro, in vivo, ex vivo or in silico. The Journal is a forum for recent scientific information and developments in the discipline of veterinary pharmacology, including toxicology and therapeutics. Studies that are entirely in vitro will not be considered within the scope of JVPT unless the study has direct relevance to the use of the drug (including toxicants and feed additives) in veterinary species, or that it can be clearly demonstrated that a similar outcome would be expected in vivo. These studies should consider approved or widely used veterinary drugs and/or drugs with broad applicability to veterinary species.
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