The 2910-nm Fiber Laser Is Safe and Effective for Improving Acne Scarring

IF 2.2 3区 医学 Q2 DERMATOLOGY Lasers in Surgery and Medicine Pub Date : 2024-09-22 DOI:10.1002/lsm.23845
Eric Bernstein, Ali Alajmi, Jennifer Wang, Edward Hochman, Brian Biesman, James F. Sanzo
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Abstract

Background

Acne scarring results from the inflammation associated with acne papules, which alters dermal collagen, typically producing depressed scars. Lasers have been used to remodel skin improving the texture and appearance of acne scars. Herein, we investigate a new 2910 nm, erbium-doped, fluoride glass, fiber laser for improving acne scars. This novel laser delivers up to 5000 Hz low-energy pulses, providing a unique treatment modality.

Methods

Fourteen subjects with rolling and/or boxcar acne scars were enrolled in this study. Thirteen subjects completed the final visit and received three treatments with the 2910 nm fiber laser at 6–8-week intervals. Eight subjects were Fitzpatrick type II and five were Fitzpatrick type III. Digital images were taken pre- and 1- and 3-months posttreatment and evaluated by two blinded reviewers in a randomized fashion for improvement. Subjects and the treating physician completed a Global Aesthetic Improvement Scale (GAIS) before treatment and at each visit to subjectively evaluate treatment effect. Histological analysis was performed on ex vivo lower eyelid skin samples. Side effects were evaluated by the treating physician and included erythema, edema, and pinpoint bleeding.

Results

Evaluation of blinded digital images revealed a mean improvement of 47.3% ± 14.2% (mean ± SEM) 3 months following the final treatment. GAIS scores demonstrated improvement as evaluated by both the subjects and the treating physician. Side effects averaged trace-to-mild erythema, edema, and pinpoint bleeding.

Conclusion

This study shows that the 2910 nm, erbium-doped, fluoride glass, fiber laser is safe and effective for improving the appearance of acne scars.

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2910 波长光纤激光器可安全有效地改善痤疮疤痕。
背景:痤疮疤痕是由于痤疮丘疹引起的炎症改变了真皮胶原蛋白,通常会产生凹陷性疤痕。激光已被用于重塑皮肤,改善痤疮疤痕的质地和外观。在此,我们研究了一种用于改善痤疮疤痕的新型 2910 纳米掺铒氟化玻璃光纤激光器。这种新型激光可发出高达 5000 Hz 的低能量脉冲,提供了一种独特的治疗方式:本研究共招募了 14 名患有滚动式和/或箱形痤疮疤痕的受试者。13名受试者完成了最后一次检查,并在6-8周的间隔时间内接受了三次2910纳米光纤激光治疗。八名受试者为 Fitzpatrick II 型,五名为 Fitzpatrick III 型。治疗前、治疗后 1 个月和 3 个月拍摄数码图像,并由两名盲人评审员以随机方式对改善情况进行评估。受试者和主治医师在治疗前和每次就诊时都填写了全球美学改善量表(GAIS),以主观评估治疗效果。对活体下眼睑皮肤样本进行组织学分析。副作用由主治医生评估,包括红斑、水肿和针尖出血:结果:盲法数字图像评估显示,最终治疗 3 个月后,平均改善率为 47.3% ± 14.2%(平均值 ± SEM)。根据受试者和主治医生的评估,GAIS 评分均有所改善。副作用平均为微量至轻度红斑、水肿和针尖出血:这项研究表明,2910 纳米掺铒氟化玻璃光纤激光器对改善痤疮疤痕外观安全有效。
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来源期刊
CiteScore
5.40
自引率
12.50%
发文量
119
审稿时长
1 months
期刊介绍: Lasers in Surgery and Medicine publishes the highest quality research and clinical manuscripts in areas relating to the use of lasers in medicine and biology. The journal publishes basic and clinical studies on the therapeutic and diagnostic use of lasers in all the surgical and medical specialties. Contributions regarding clinical trials, new therapeutic techniques or instrumentation, laser biophysics and bioengineering, photobiology and photochemistry, outcomes research, cost-effectiveness, and other aspects of biomedicine are welcome. Using a process of rigorous yet rapid review of submitted manuscripts, findings of high scientific and medical interest are published with a minimum delay.
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