Frailty for neurologists: perspectives on how frailty influences care planning.

IF 46.5 1区 医学 Q1 CLINICAL NEUROLOGY Lancet Neurology Pub Date : 2024-11-01 Epub Date: 2024-09-11 DOI:10.1016/S1474-4422(24)00291-6
Marco Canevelli, Caitlin Jackson-Tarlton, Kenneth Rockwood
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引用次数: 0

Abstract

The concept of frailty, now being adopted in most medical disciplines, is attracting growing interest in neurology. Every day, most neurologists care for patients with varying degrees of frailty, from very mild to very severe. Frailty exacerbates patients' health needs, complicates clinical decision making, and negatively affects their health outcomes. Increasing evidence suggests that frailty affects the risk, clinical presentation, and course of common age-related neurological disorders, including dementia, Parkinson's disease, stroke, and multiple sclerosis. Most neurologists should become familiar with assessing and measuring frailty. Doing so can provide information that is crucial for diagnosis, prognostication, and care planning. Consideration of frailty can help to elucidate the pathophysiological underpinnings of age-related neurological disorders, clarify the clinical validity and utility of candidate biomarkers, and identify novel therapeutic targets. Randomised controlled trials investigating late-life neurological diseases that address frailty have the potential to provide insight into these complex disorders.

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神经科医生的虚弱问题:关于虚弱如何影响护理规划的观点。
虚弱(frailty)这一概念目前已被大多数医学学科所采用,在神经病学领域也引起了越来越多的关注。每天,大多数神经科医生都要照顾不同程度的虚弱患者,从非常轻微到非常严重不等。虚弱会加剧患者的健康需求,使临床决策复杂化,并对其健康结果产生负面影响。越来越多的证据表明,虚弱会影响常见的与年龄相关的神经系统疾病,包括痴呆症、帕金森病、中风和多发性硬化症的风险、临床表现和病程。大多数神经科医生都应熟悉评估和测量虚弱程度。这样做可以提供对诊断、预后和护理计划至关重要的信息。考虑虚弱问题有助于阐明与年龄相关的神经系统疾病的病理生理学基础,明确候选生物标志物的临床有效性和实用性,并确定新的治疗目标。针对虚弱状态的晚年神经系统疾病的随机对照试验有可能帮助人们深入了解这些复杂的疾病。
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来源期刊
Lancet Neurology
Lancet Neurology 医学-临床神经学
CiteScore
58.70
自引率
1.00%
发文量
572
审稿时长
6-12 weeks
期刊介绍: The Lancet Neurology is the world-leading clinical neurology journal. It publishes original research that advocates for change in, or sheds light on, neurological clinical practice. The topics covered include cerebrovascular disease, Alzheimer's disease and other dementias, epilepsy, migraine, neurological infections, movement disorders, multiple sclerosis, neuromuscular disorders, peripheral nerve disorders, pediatric neurology, sleep disorders, and traumatic brain injury. The journal publishes a range of article types, including Articles (including randomized clinical trials and meta-analyses), Review, Rapid Review, Comment, Correspondence, and Personal View. It also publishes Series and Commissions that aim to shape and drive positive change in clinical practice and health policy in areas of need in neurology. The Lancet Neurology is an internationally trusted source of clinical, public health, and global health knowledge. It has an Impact Factor of 48.0, making it the top-ranked clinical neurology journal out of 212 journals worldwide.
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