Acupuncture for the treatment of anxiety and depression in patients with spinal cord injury: A study protocol for systematic review and meta analysis.

IF 1.3 4区医学 Q2 MEDICINE, GENERAL & INTERNAL Medicine Pub Date : 2024-09-20 DOI:10.1097/MD.0000000000039701

Ke Liu, Xiaoyong Gao, Liang Ou, Zuyu Tang, Haoming Zhao, Sheng Hua, Yixiao Xiong, Le Zhang, Jianjun Kuang

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Abstract

Background: Spinal cord injury patients frequently suffer from anxiety and depression, which can seriously affect their quality of life and recovery. Acupuncture, as a traditional Chinese therapy, has been used to treat anxiety and depression for more than 2000 years. The aim is to evaluate the clinical efficacy of acupuncture in the treatment of anxiety and depression in spinal cord injury patients.

Methods: The literature on acupuncture treating anxiety and depression in patients with spinal cord injury in PubMed, Embase, Cochrane Library, Chinese Biomedical Literature Database, China National Knowledge Infrastructure, Chinese Scientific Journal Data, and Wanfang data were searched through computers from the establishment of the database to May 2024. In the study, the Cochrane tool for assessing the risk of bias was used and the meta-analyses were carried out using the software package Review Manager 5.4.

Results: Ten trials were included in this systematic review, with 361 cases in the experimental group and 355 cases in the control group. Meta-analysis showed that compared with conventional treatment, acupuncture combined with conventional treatment was beneficial in improving the total clinical efficacy (odds ratio = 3.55 [95% confidence interval {CI}: 1.34-9.37], P < .001). We found acupuncture-assisted therapy could be beneficial in improving the Modified Barthel Index (MD = 10.48 [95% CI: 4.78-16.19], P < .001) and reducing anxiety or depression scores (such as the Self-Rating Anxiety Scale [MD = -6.08 {95% CI: -6.85 to -5.30}, P < .001]; reducing the Self-Rating Depression Scale [MD = -6.01 {95% CI: -6.95 to -5.07}, P < .001]). In addition, the study showed that the application of acupuncture treatment could improve 5-hydroxytryptamine compared to control group (MD = 44.99 [95% CI: 40.04-49.95], P < .001) and reduce TNF-α compared to control group (MD = -7.78 [95% CI: -8.73 to -6.83], P < .001).

Conclusion: Acupuncture could be used as a complementary therapy to reduce anxiety and depression in spinal cord injury patients. Further original and high-quality research is needed to verify the conclusions of this study.

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针灸治疗脊髓损伤患者的焦虑和抑郁：系统综述和荟萃分析研究方案。

背景：脊髓损伤患者经常会出现焦虑和抑郁，这会严重影响他们的生活质量和康复。针灸作为一种传统中医疗法，用于治疗焦虑和抑郁已有 2000 多年的历史。本研究旨在评估针灸治疗脊髓损伤患者焦虑和抑郁的临床疗效：方法：通过计算机检索自数据库建立至2024年5月期间PubMed、Embase、Cochrane图书馆、中国生物医学文献数据库、中国国家知识基础设施、中文科技期刊资料和万方数据中有关针灸治疗脊髓损伤患者焦虑和抑郁的文献。研究中使用了Cochrane偏倚风险评估工具，并使用Review Manager 5.4软件包进行了荟萃分析：本系统综述共纳入 10 项试验，其中实验组 361 例，对照组 355 例。元分析表明，与常规治疗相比，针灸联合常规治疗有利于提高临床总疗效（几率比=3.55[95%置信区间{CI}：1.34-9.37]，P 结论：针灸可作为一种有效的治疗手段：针灸可作为一种辅助疗法，减轻脊髓损伤患者的焦虑和抑郁。要验证本研究的结论，还需要进一步的原创性高质量研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Medicine 医学-医学：内科

CiteScore

2.80

自引率

0.00%

发文量

4342

审稿时长

>12 weeks

期刊介绍： Medicine is now a fully open access journal, providing authors with a distinctive new service offering continuous publication of original research across a broad spectrum of medical scientific disciplines and sub-specialties. As an open access title, Medicine will continue to provide authors with an established, trusted platform for the publication of their work. To ensure the ongoing quality of Medicine’s content, the peer-review process will only accept content that is scientifically, technically and ethically sound, and in compliance with standard reporting guidelines.