Folate intake and the risk of endometrial cancer: A dose-response meta-analysis.

IF 1.3 4区医学 Q2 MEDICINE, GENERAL & INTERNAL Medicine Pub Date : 2024-09-20 DOI:10.1097/MD.0000000000039775

Jiaye Long, Du Wang, Miyang Yang, Yingrong Pang, Meiqiong Li, Shuxin Qin, Kai Cui

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Abstract

Background: The relationship between folate intake and risk of endometrial cancer (EC) is debatable. The goal of this study was to examine the relationship between folate consumption and EC and then conduct a dose-response analysis in accordance with this.

Methods: Up until February 1, 2024, we conducted a thorough search using PubMed, EMBASE, the Cochrane Library, and Web of Science. Stata 14 software was used to analyze the findings of the article. The study protocol was registered in PROSPERO (CRD42024505943), and the meta-analysis was conducted in accordance with PRISMA guidelines.

Results: Nine case-control studies and 6 cohort studies were included, comprising 379,570 participants and 8660 EC cases. The highest level of folate consumption was associated with a 10% reduction in the occurrence of EC (relative risk [RR] = 0.90, 95% confidence intervals [CIs]: 0.78-1.05, I2 = 63.2%) compared to the lowest level of intake. The association exhibited a statistically significant linear trend (P = .231), with a combined RR of 0.974 (95% CI: 0.968-0.981) for each daily intake of 50 µg folate.

Conclusion: Folate intake may reduce the risk of EC.

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叶酸摄入量与子宫内膜癌风险：剂量反应荟萃分析。

背景：叶酸摄入量与子宫内膜癌（EC）风险之间的关系尚存争议。本研究的目的是探讨叶酸摄入量与子宫内膜癌之间的关系，并据此进行剂量反应分析：截至 2024 年 2 月 1 日，我们使用 PubMed、EMBASE、Cochrane 图书馆和 Web of Science 进行了全面搜索。使用Stata 14软件对文章结果进行分析。研究方案已在 PROSPERO（CRD42024505943）上注册，荟萃分析按照 PRISMA 指南进行：结果：共纳入了 9 项病例对照研究和 6 项队列研究，包括 379 570 名参与者和 8660 个欧共体病例。叶酸摄入量越高，心肌梗死发生率越低 10%（相对风险 [RR] = 0.90，95% 置信区间 [CIs]：0.78-1.05，I.C.）：0.78-1.05, I2 = 63.2%）。该关联呈现出具有统计学意义的线性趋势（P = .231），每日叶酸摄入量每增加 50 微克，综合 RR 为 0.974（95% 置信区间：0.968-0.981）：结论：叶酸摄入量可降低罹患心肌梗死的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Medicine 医学-医学：内科

CiteScore

2.80

自引率

0.00%

发文量

4342

审稿时长

>12 weeks

期刊介绍： Medicine is now a fully open access journal, providing authors with a distinctive new service offering continuous publication of original research across a broad spectrum of medical scientific disciplines and sub-specialties. As an open access title, Medicine will continue to provide authors with an established, trusted platform for the publication of their work. To ensure the ongoing quality of Medicine’s content, the peer-review process will only accept content that is scientifically, technically and ethically sound, and in compliance with standard reporting guidelines.