Association between PAI-1 4G/5G genotype and residual thrombus in acute mesenteric venous thrombosis.

IF 2.6 4区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Molecular Biology Reports Pub Date : 2024-09-20 DOI:10.1007/s11033-024-09947-y

Bin Liu, Hai Feng, Wenrui Li

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引用次数: 0

Abstract

Objective: Plasminogen activator inhibitor-1 (PAI-1) is the most important inhibitor of plasminogen activator. The functional 4G/5G polymorphism of the gene coding for PAI-1 may affect PAI-1 plasmatic activity, influencing the imbalance between coagulation and fibrinolysis cascades. In this study, we investigated the association between the PAI-1 4G/5G genotype and the development and residual thrombus of acute primary mesenteric venous thrombosis (MVT).

Methods: The clinical data of 34 patients who underwent acute primary MVT were retrospectively reviewed. Fluorescence in situ hybridization was used to determine if patients had the 4G/5G polymorphism in the promoter of the PAI-1 gene. Patients were stratified according to the genotype of PAI-1.

Results: 11 patients (32.3%) were homozygous for the 4G genotype, 23 patients (67.6%) were non-homozygous for the 4G genotype (5G/5G). The extent of thrombosis was not correlated with the PAI-4G/5G polymorphism. After a mean follow-up of 16.6 ± 10.4 months, the 4G/4G genotype had a significantly larger thrombus burden (p < 0.05). 54% of patients in the 4G/4G genotype group had no lessening in the degree of mesenteric venous thrombosis, significantly higher than other patients (4G/5G + 5G/5G genotypes) (p < 0.05).

Conclusion: The PAI-1 4G/4G predicts residual thrombus of mesenteric veins after the acute phase.

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PAI-1 4G/5G 基因型与急性肠系膜静脉血栓残余血栓之间的关系

目的：纤溶酶原激活物抑制剂-1（PAI-1）是纤溶酶原激活物最重要的抑制剂。编码 PAI-1 基因的 4G/5G 功能多态性可能会影响 PAI-1 的血浆活性，从而影响凝血和纤维蛋白溶解级联之间的失衡。本研究探讨了 PAI-1 4G/5G 基因型与急性原发性肠系膜静脉血栓（MVT）的发生和残留血栓之间的关系：方法：回顾性分析34例急性原发性肠系膜静脉血栓患者的临床资料。采用荧光原位杂交技术确定患者是否存在 PAI-1 基因启动子的 4G/5G 多态性。根据 PAI-1 基因型对患者进行分层：结果：11 名患者（32.3%）为 4G 基因型同源，23 名患者（67.6%）为非 4G 基因型同源（5G/5G）。血栓形成的程度与 PAI-4G/5G 多态性无关。在平均 16.6 ± 10.4 个月的随访后，4G/4G 基因型的血栓负荷明显增加（p 结论：PAI-1 4G/4G 多态性与血栓形成程度无关：PAI-1 4G/4G 可预测急性期后肠系膜静脉的残余血栓。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular Biology Reports 生物-生化与分子生物学

CiteScore

5.00

自引率

0.00%

发文量

1048

审稿时长

5.6 months

期刊介绍： Molecular Biology Reports publishes original research papers and review articles that demonstrate novel molecular and cellular findings in both eukaryotes (animals, plants, algae, funghi) and prokaryotes (bacteria and archaea).The journal publishes results of both fundamental and translational research as well as new techniques that advance experimental progress in the field and presents original research papers, short communications and (mini-) reviews.