{"title":"Metabolite dependence of antibiotic susceptibility in a gut microbe.","authors":"Kyle R Allison","doi":"10.1128/msphere.00600-24","DOIUrl":null,"url":null,"abstract":"<p><p>Antibiotics save lives but can have unwanted effects on our gut microbes, thereby contributing to disease. A mechanistic understanding of how such microbes respond to antibiotics is hence critical. Recently in <i>mSphere</i>, Nilson et al. investigated the metabolite dependence of antibiotic susceptibility in <i>Bacteroides thetaiotaomicron</i>, an abundant and important member of our gut microbiota (R. Nilson, S. Penumutchu, F. S. Pagano, and P. Belenky, mSphere 9:e00103-24, 2024, https://doi.org/10.1128/msphere.00103-24). Their uncovered findings suggest the possibility of potentiating antibiotics with metabolites to reduce post-antibiotic \"blooming\" of <i>B. thetaiotaomicron</i> and the associated development of gut symbiosis.</p>","PeriodicalId":19052,"journal":{"name":"mSphere","volume":" ","pages":"e0060024"},"PeriodicalIF":3.7000,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11520300/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"mSphere","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1128/msphere.00600-24","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/9/19 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"MICROBIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Antibiotics save lives but can have unwanted effects on our gut microbes, thereby contributing to disease. A mechanistic understanding of how such microbes respond to antibiotics is hence critical. Recently in mSphere, Nilson et al. investigated the metabolite dependence of antibiotic susceptibility in Bacteroides thetaiotaomicron, an abundant and important member of our gut microbiota (R. Nilson, S. Penumutchu, F. S. Pagano, and P. Belenky, mSphere 9:e00103-24, 2024, https://doi.org/10.1128/msphere.00103-24). Their uncovered findings suggest the possibility of potentiating antibiotics with metabolites to reduce post-antibiotic "blooming" of B. thetaiotaomicron and the associated development of gut symbiosis.
抗生素能拯救生命，但也会对我们的肠道微生物产生不必要的影响，从而导致疾病。因此，从机理上了解这些微生物如何对抗生素做出反应至关重要。最近，Nilson 等人在 mSphere 上研究了 Bacteroides thetaiotaomicron 对抗生素敏感性的代谢物依赖性，Bacteroides thetaiotaomicron 是我们肠道微生物群中丰富而重要的成员（R. Nilson, S. Penumutchu, F. S. Pagano, and P. Belenky, mSphere 9:e00103-24, 2024, https://doi.org/10.1128/msphere.00103-24）。他们的研究结果表明，有可能用代谢物增强抗生素的效力，以减少抗生素后 B. thetaiotaomicron 的 "繁殖 "以及肠道共生的相关发展。
期刊介绍：
mSphere™ is a multi-disciplinary open-access journal that will focus on rapid publication of fundamental contributions to our understanding of microbiology. Its scope will reflect the immense range of fields within the microbial sciences, creating new opportunities for researchers to share findings that are transforming our understanding of human health and disease, ecosystems, neuroscience, agriculture, energy production, climate change, evolution, biogeochemical cycling, and food and drug production. Submissions will be encouraged of all high-quality work that makes fundamental contributions to our understanding of microbiology. mSphere™ will provide streamlined decisions, while carrying on ASM''s tradition for rigorous peer review.
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