Unraveling Quercetin's Potential: A Comprehensive Review of Its Properties and Mechanisms of Action, in Diabetes and Obesity Complications.

IF 6.1 2区医学 Q1 CHEMISTRY, MEDICINAL Phytotherapy Research Pub Date : 2024-09-22 DOI:10.1002/ptr.8332

Ruhan Yi, Yun Liu, Xu Zhang, Xiance Sun, Ningning Wang, Cong Zhang, Haoyuan Deng, Xiaofeng Yao, Shaopeng Wang, Guang Yang

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Abstract

The prevalence of diabetes is escalating alarmingly, placing a significant economic burden on the global healthcare system. The use of chemical substances extracted from plants has been demonstrated to be an effective method for the treatment and control of insulin resistance and Type 2 diabetes mellitus (T2DM). New research indicates that natural phytochemicals present in fruits and vegetables are expected to become drugs for the treatment of diabetes and the prevention of related complications. Quercetin, a widely distributed flavonoid, is well-known for its antioxidant, anti-inflammatory, anticancer, and antidiabetic properties. This article provides a comprehensive account of the mechanism of action of quercetin on diabetes and obesity complications in vivo and in vitro. It elucidates the impact of quercetin on various cells. These include hepatocytes, renal cells, skeletal muscle cells, and adipocytes. Furthermore, this article discusses the mechanism of quercetin on organ damage in diabetic mice induced by STZ, alloxan, diet, and spontaneous Type 2 diabetic mice caused by genetic defects. Additionally, it addresses the pharmacokinetics of quercetin and its potential for synergistic effects with existing diabetic drugs.

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揭示槲皮素的潜力：糖尿病和肥胖症并发症》中的《槲皮素的潜力：其特性和作用机制的全面回顾》。

糖尿病的发病率正在以惊人的速度上升，给全球医疗保健系统带来了巨大的经济负担。使用从植物中提取的化学物质已被证明是治疗和控制胰岛素抵抗和 2 型糖尿病（T2DM）的有效方法。新的研究表明，水果和蔬菜中的天然植物化学物质有望成为治疗糖尿病和预防相关并发症的药物。槲皮素是一种广泛分布的类黄酮，以其抗氧化、抗炎、抗癌和抗糖尿病特性而闻名。本文全面阐述了槲皮素在体内和体外对糖尿病和肥胖症并发症的作用机制。文章阐明了槲皮素对各种细胞的影响。这些细胞包括肝细胞、肾细胞、骨骼肌细胞和脂肪细胞。此外，本文还讨论了槲皮素对 STZ、阿脲、饮食诱导的糖尿病小鼠和因基因缺陷导致的自发性 2 型糖尿病小鼠器官损伤的机制。此外，文章还探讨了槲皮素的药代动力学及其与现有糖尿病药物协同作用的潜力。

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来源期刊

Phytotherapy Research 医学-药学

CiteScore

12.80

自引率

5.60%

发文量

325

审稿时长

2.6 months

期刊介绍： Phytotherapy Research is an internationally recognized pharmacological journal that serves as a trailblazing resource for biochemists, pharmacologists, and toxicologists. We strive to disseminate groundbreaking research on medicinal plants, pushing the boundaries of knowledge and understanding in this field. Our primary focus areas encompass pharmacology, toxicology, and the clinical applications of herbs and natural products in medicine. We actively encourage submissions on the effects of commonly consumed food ingredients and standardized plant extracts. We welcome a range of contributions including original research papers, review articles, and letters. By providing a platform for the latest developments and discoveries in phytotherapy, we aim to support the advancement of scientific knowledge and contribute to the improvement of modern medicine.