The Impact of COVID-19 Third Dose Vaccination on the Magnitude of Antigen Specific T Cells in Kidney Transplant Patients.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-08-31

E Girmanova, J Duskova, P Mrazova, M Fialova, O Viklicky, P Hruba

引用次数: 0

Abstract

Measuring T cell response can add information about antivirus immunity provided by antibody test results. The study evaluates the impact of a third mRNA COVID-19 vaccine dose on T cell response and antibody production in kidney transplant recipients (25 KTRs) versus healthy controls (26 Hc). Results show a significant rise in S-activated CD4+CD154+IFN?+TNF?+ double producer cells in both KTRs (p=0.025) and Hc (p=0.009) as well as increased spike antibody response in KTRs (p=0.00019) and Hc (p=3.10-8) third-month post-third dose. Moreover, the study revealed a drop in seronegative KTRs (non-responders) from 9/25 (36%) pre-third dose to 2/25 (7%) at 3 months post-third dose while 5/9 (56%) of non-responders post-second dose showed specific T cell responses. Notably, the third dose significantly improved seroconversion rates in both KTRs and Hc, although Hc individuals exhibited higher antibody levels. Key words: mRNA COVID-19 vaccine, T cells, SARS-CoV-2 antibodies, Kidney transplantation, mRNA vaccination.

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COVID-19 第三剂量疫苗接种对肾移植患者抗原特异性 T 细胞数量的影响

测量 T 细胞反应可以补充抗体检测结果所提供的抗病毒免疫信息。该研究评估了第三剂 mRNA COVID-19 疫苗对肾移植受者（25 名 KTR）与健康对照组（26 名 Hc）的 T 细胞应答和抗体产生的影响。结果显示，KTRs（p=0.025）和Hc（p=0.009）中的S激活CD4+CD154+IFN?+TNF?+双生产者细胞均明显增加，KTRs（p=0.00019）和Hc（p=3.10-8）中的尖峰抗体反应也在第三剂后的第三个月有所增加。此外，研究还发现血清阴性的 KTR（无应答者）从第三剂前的 9/25（36%）下降到第三剂后 3 个月的 2/25（7%），而第二剂后 5/9（56%）的无应答者出现了特异性 T 细胞应答。值得注意的是，第三剂明显提高了KTR和Hc的血清转换率，尽管Hc个体表现出更高的抗体水平。关键词：mRNA COVID-19 疫苗、T 细胞、SARS-CoV-2 抗体、肾移植、mRNA 疫苗接种。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.

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