Psoriasis in women with psoriatic arthritis: hormonal effects, fertility, and considerations for management at different stages of life.

IF 1.2 Q4 RHEUMATOLOGY Reumatismo Pub Date : 2024-09-11 DOI:10.4081/reumatismo.2024.1775

F Cassalia, A Belloni Fortina

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引用次数: 0

Abstract

Objective: This review examines skin manifestations in women with spondyloarthritis, with a particular focus on psoriatic arthritis (PsA) and associated psoriasis.

Methods: A narrative review of the bibliography was conducted using the main databases (PubMed, Scopus, EMBASE).

Results: The review showed that the clinical course of PsA and psoriasis in women is influenced by hormonal fluctuations that occur at different stages of life, such as menstruation, pregnancy, postpartum, and menopause. Gender differences in the epidemiology of PsA and psoriasis are discussed and attributed to biological, hormonal, and environmental differences. The role of estrogen in modulating immune responses and its impact on the severity of PsA and psoriasis are reviewed. Special emphasis is placed on the psychosocial impact of visible skin lesions on women's quality of life and fertility problems associated with psoriasis. Treatment strategies are also taken into account, favoring personalized approaches that consider the safety of treatments during pregnancy and breastfeeding.

Conclusions: The review highlights the importance of a holistic and gender-sensitive approach to the management of PsA and psoriasis in women, promoting the integration of physical treatment with support for emotional well-being.

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患有银屑病关节炎的女性银屑病患者：荷尔蒙影响、生育以及不同生命阶段的管理注意事项。

目的：本综述研究了患有脊柱关节炎的女性的皮肤表现，尤其关注银屑病关节炎（PsA）和相关的银屑病：本综述研究了患有脊柱关节炎的女性患者的皮肤表现，尤其关注银屑病关节炎（PsA）和相关的银屑病：方法：使用主要数据库（PubMed、Scopus、EMBASE）对文献进行叙述性综述：结果：综述显示，女性 PsA 和银屑病的临床病程受月经期、妊娠期、产后和更年期等人生不同阶段荷尔蒙波动的影响。本文讨论了 PsA 和银屑病流行病学中的性别差异，并将其归因于生物、激素和环境差异。回顾了雌激素在调节免疫反应中的作用及其对 PsA 和银屑病严重程度的影响。特别强调了可见皮损对女性生活质量的社会心理影响以及与银屑病相关的生育问题。此外，还考虑了治疗策略，倾向于采用考虑到妊娠期和哺乳期治疗安全性的个性化方法：本综述强调了在治疗女性 PsA 和银屑病时采用整体和性别敏感方法的重要性，提倡将物理治疗与情感支持相结合。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Reumatismo RHEUMATOLOGY-

CiteScore

2.10

自引率

7.10%

发文量

审稿时长

10 weeks

期刊介绍： Reumatismo is the official Journal of the Italian Society of Rheumatology (SIR). It publishes Abstracts and Proceedings of Italian Congresses and original papers concerning rheumatology. Reumatismo is published quarterly and is sent free of charge to the Members of the SIR who regularly pay the annual fee. Those who are not Members of the SIR as well as Corporations and Institutions may also subscribe to the Journal.