Intraday Variations in Skin Water Parameters.

IF 2.8 4区 医学 Q2 DERMATOLOGY Skin Pharmacology and Physiology Pub Date : 2024-09-19 DOI:10.1159/000541547
Harvey N Mayrovitz
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Abstract

Introduction: Three interrelated skin water assessments include stratum corneum hydration (SCH) via electrical measurements, skin water using tissue dielectric constant (TDC) measurements, and transepidermal water loss (TEWL). These are differentially used for skin physiology research, clinical assessments of dermatological conditions and to assess skin water in diabetes and lymphedema. Often volar forearm skin is used for assessments done at various times of day (TOD). The present goal was to assess the extent of intraday variability in SCH, TDC, and TEWL.

Methods: Twelve medical students self-measured SCH, TDC, and TEWL on their forearm every 2 h from 08:00 to 24:00 h on 2 consecutive days. All participants were well trained and pre-certified in all procedures. Tests for parameter differences among TOD were via the nonparametric Friedman test.

Results: No significant differences in SCH or TEWL were found among TOD over the 16-h interval for either day or combined. Contrastingly, TDC decreased slightly but significantly from morning through evening. There was no evidence of a diurnal pattern. Interestingly, a significant nonlinear relationship between TEWL and SCH was detected.

Conclusion: Findings indicate only minor intraday variations with TOD trend except for TDC which decreases slightly from morning through evening. The clinical relevance relates to the confidence now gained associated with the parameter estimates when measured at different TOD during normal clinic hours or beyond. This should help in estimating the potential importance of small differences if measured at a different TOD. From a physiological viewpoint, the findings uncover and describe an interesting nonlinear relationship between TEWL and SCH which may serve to propel further investigations that might better characterize this process.

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皮肤水参数的日内变化
导言:三种相互关联的皮肤水分评估方法包括通过电测量进行的角质层水合(SCH)、通过组织介电常数(TDC)测量进行的皮肤水分和经表皮失水(TEWL)。这些方法分别用于皮肤生理学研究、皮肤病临床评估以及糖尿病和淋巴水肿的皮肤水分评估。通常情况下,在一天中的不同时间(TOD)对前臂皮肤进行评估。本研究旨在评估SCH、TDC和TEWL的日内变化程度:方法:12 名医科学生在连续两天的 8:00 至 24:00 期间,每隔两小时对前臂的 SCH、TDC 和 TEWL 进行一次自我测量。所有参与者均接受过良好的培训,并预先获得了所有程序的认证。通过非参数弗里德曼检验法检验 TOD 之间的参数差异:结果:在 16 小时的时间间隔内,TOD 之间的 SCH 或 TEWL 在日间和夜间均无明显差异。相反,TDC 从早到晚略有下降,但降幅明显。没有证据表明存在昼夜模式。有趣的是,TEWL 和 SCH 之间存在明显的非线性关系:结论:研究结果表明,除了 TDC 从早到晚略有下降外,TOD 的日间变化趋势很小。其临床意义在于,在正常门诊时间或更长的时间内,在不同的 TOD 下测量参数估计值时,现在可以获得相关的置信度。如果在不同的 TOD 测量,这将有助于估计微小差异的潜在重要性。从生理学的角度来看,研究结果发现并描述了 TEWL 和 SCH 之间有趣的非线性关系,这可能有助于推动进一步的研究,从而更好地描述这一过程。
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来源期刊
Skin Pharmacology and Physiology
Skin Pharmacology and Physiology 医学-皮肤病学
CiteScore
5.20
自引率
7.40%
发文量
23
审稿时长
>12 weeks
期刊介绍: In the past decade research into skin pharmacology has rapidly developed with new and promising drugs and therapeutic concepts being introduced regularly. Recently, the use of nanoparticles for drug delivery in dermatology and cosmetology has become a topic of intensive research, yielding remarkable and in part surprising results. Another topic of current research is the use of tissue tolerable plasma in wound treatment. Stimulating not only wound healing processes but also the penetration of topically applied substances into the skin, this novel technique is expected to deliver very interesting results.
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