{"title":"Ergostanes from the mushroom Trametes versicolor and their cancer cell inhibition: In vitro and in silico evaluation","authors":"","doi":"10.1016/j.steroids.2024.109511","DOIUrl":null,"url":null,"abstract":"<div><div>In this study, five steroid compounds were isolated from the fruiting bodies mushroom <em>Trametes versicolor.</em> The compounds, 9,19-cyclolanostane-3,29-diol (<strong>3</strong>), ergosta-7,22-dien-3-acetate (<strong>4</strong>), and ergosta-8(14),22-dien-3β,5α,6β,7α-tetrol (<strong>5</strong>), were identified from <em>T. versicolor</em> for the first time. The five compounds were evaluated for their activity against cancer cell lines. Compound 5α,8α–epidioxyergosta-6,22-dien-3β-ol (<strong>1</strong>) was found to be the most effective against most of the cancer cell lines tested. <em>In silico</em> studies showed that compound <strong>1</strong> has good binding affinities to different cancer targets, namely cyclin-dependent kinase 2 (cdk2), human cyclin-dependent kinase 6 (cdk6), Human Topo IIa ATPase/AMP-PNP, anti-apoptotic protein Bcl-2, and Vegfr-2. It’s also druglike based on Lipinski’s rule of five and it’s ADME/Tox properties. Therefore, compound <strong>1</strong> is a good candidate in the management of cancer. These results further show that <em>T. versicolor</em> is a potential source of drugs or drug leads for cancer treatment.</div></div>","PeriodicalId":21997,"journal":{"name":"Steroids","volume":null,"pages":null},"PeriodicalIF":2.1000,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Steroids","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0039128X24001491","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
In this study, five steroid compounds were isolated from the fruiting bodies mushroom Trametes versicolor. The compounds, 9,19-cyclolanostane-3,29-diol (3), ergosta-7,22-dien-3-acetate (4), and ergosta-8(14),22-dien-3β,5α,6β,7α-tetrol (5), were identified from T. versicolor for the first time. The five compounds were evaluated for their activity against cancer cell lines. Compound 5α,8α–epidioxyergosta-6,22-dien-3β-ol (1) was found to be the most effective against most of the cancer cell lines tested. In silico studies showed that compound 1 has good binding affinities to different cancer targets, namely cyclin-dependent kinase 2 (cdk2), human cyclin-dependent kinase 6 (cdk6), Human Topo IIa ATPase/AMP-PNP, anti-apoptotic protein Bcl-2, and Vegfr-2. It’s also druglike based on Lipinski’s rule of five and it’s ADME/Tox properties. Therefore, compound 1 is a good candidate in the management of cancer. These results further show that T. versicolor is a potential source of drugs or drug leads for cancer treatment.
期刊介绍：
STEROIDS is an international research journal devoted to studies on all chemical and biological aspects of steroidal moieties. The journal focuses on both experimental and theoretical studies on the biology, chemistry, biosynthesis, metabolism, molecular biology, physiology and pharmacology of steroids and other molecules that target or regulate steroid receptors. Manuscripts presenting clinical research related to steroids, steroid drug development, comparative endocrinology of steroid hormones, investigations on the mechanism of steroid action and steroid chemistry are all appropriate for submission for peer review. STEROIDS publishes both original research and timely reviews. For details concerning the preparation of manuscripts see Instructions to Authors, which is published in each issue of the journal.
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