Serum vascular endothelial growth factor has diagnostic and prognostic significance in ulcerative colitis.

IF 1.2 4区医学 Q2 MEDICINE, GENERAL & INTERNAL Turkish Journal of Medical Sciences Pub Date : 2024-05-17 eCollection Date: 2024-01-01 DOI:10.55730/1300-0144.5841

Musa Salmanoğlu, İrfan Küçük, Başak Çakir Güney, Betül Doğantekin, Nurgül Tükel, Zeliha Serindağ, Habip Yilmaz, Mustafa Kaplan

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Abstract

Background/aim: In ulcerative colitis (UC), serum vascular endothelial growth factor (sVEGF) concentrations are elevated and there are conflicting results about serum calprotectin (SCP) and sVEGF as biomarkers. We aimed to evaluate the relationship between sVEGF and SCP levels in UC patients and the associations of these molecules with the phenotypes of UC.

Materials and methods: This prospective case-control study included 60 UC patients and 30 healthy controls. The Mayo Clinical Score (MCS) was used to evaluate patients' clinical features and the Mayo Endoscopic Score (MES) was used to evaluate endoscopic features of the cases. The method proposed by Truelove and Richards was applied in calculating the histology activity index (HAI). Human sVEGF (Cat.E0080Hu) and human calprotectin (Cat.E4010Hu) kits were used for the enzyme-linked immunosorbent assay (ELISA) measurements of sVEGF and SCP levels.

Results: The median sVEGF and SCP levels were higher in the patient group compared to the healthy control group [2139 ng/L (126-5783) vs. 888 ng/L (715-5270), p = 0.002 and 932 ng/L (99-2648) vs. 80 ng/L (56-920), p < 0.001, respectively]. There was a strong correlation between SCP and sVEGF values (rho = 0.819, p < 0.001). The MCS, MES, and HAI values were positively correlated with sVEGF and SCP concentrations.

Conclusion: sVEGF and SCP may be valuable auxiliary biomarkers for UC.

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血清血管内皮生长因子对溃疡性结肠炎具有诊断和预后意义。

背景/目的：在溃疡性结肠炎（UC）患者中，血清血管内皮生长因子（sVEGF）浓度升高，而关于血清钙蛋白（SCP）和sVEGF作为生物标志物的研究结果却相互矛盾。我们旨在评估 UC 患者体内 sVEGF 和 SCP 水平之间的关系，以及这些分子与 UC 表型之间的关联：这项前瞻性病例对照研究包括 60 名 UC 患者和 30 名健康对照者。梅奥临床评分（MCS）用于评估患者的临床特征，梅奥内镜评分（MES）用于评估病例的内镜特征。在计算组织学活性指数（HAI）时，采用了 Truelove 和 Richards 提出的方法。人 sVEGF（Cat.E0080Hu）和人钙黏蛋白（Cat.E4010Hu）试剂盒用于酶联免疫吸附试验（ELISA）测定 sVEGF 和 SCP 水平：结果：与健康对照组相比，患者组的 sVEGF 和 SCP 水平中位数更高[分别为 2139 ng/L (126-5783) vs. 888 ng/L (715-5270)，p = 0.002 和 932 ng/L (99-2648) vs. 80 ng/L (56-920)，p < 0.001]。SCP 和 sVEGF 值之间存在很强的相关性（rho = 0.819，p < 0.001）。结论：sVEGF 和 SCP 可能是 UC 有价值的辅助生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Turkish Journal of Medical Sciences 医学-医学：内科

CiteScore

4.60

自引率

4.30%

发文量

143

审稿时长

3-8 weeks

期刊介绍： Turkish Journal of Medical sciences is a peer-reviewed comprehensive resource that provides critical up-to-date information on the broad spectrum of general medical sciences. The Journal intended to publish original medical scientific papers regarding the priority based on the prominence, significance, and timeliness of the findings. However since the audience of the Journal is not limited to any subspeciality in a wide variety of medical disciplines, the papers focusing on the technical details of a given medical subspeciality may not be evaluated for publication.