Clinical profiles of multidrug-resistant and rifampicin-monoresistant tuberculosis in Korea, 2018-2021: a nationwide cross-sectional study.

IF 2.5 Q2 RESPIRATORY SYSTEM Tuberculosis and Respiratory Diseases Pub Date : 2024-09-23 DOI:10.4046/trd.2024.0049

Jinsoo Min, Yousang Ko, Hyung Woo Kim, Hyeon-Kyoung Koo, Jee Youn Oh, Doosoo Jeon, Taehoon Lee, Young-Chul Kim, Sung Chul Lim, Sung Soon Lee, Jae Seuk Park, Ju Sang Kim

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Abstract

Background: This study aimed to identify the clinical characteristics of multidrug-resistant/rifampicin-resistant tuberculosis (MDR/RR-TB) in the Republic of Korea.

Methods: Data of notified people with tuberculosis between July 2018 and December 2021 were retrieved from the Korea Tuberculosis Cohort database. MDR/RR-TB was further categorized according to isoniazid susceptibility as follows: (1) MDR-TB, (2) rifampicin-monoresistant tuberculosis (RMR-TB), and (3) RR-TB if susceptibility to isoniazid was unknown. Multivariable logistic regression analysis was conducted to identify the factors associated with MDR/RR-TB.

Results: Between 2018 and 2021, the proportion of MDR/RR-TB cases among all TB cases and TB cases with known drug susceptibility test results was 2.1% (502/24,447). The proportions of MDR/RR-TB and MDR-TB cases among TB cases with known drug susceptibility test results were 3.3% (502/15,071) and 1.9% (292/15,071), respectively. Among all cases of rifampicin resistance, 31.7% (159/502) were RMR-TB and 10.2% (51/502) were RR-TB. Multivariable logistic regression analyses revealed that younger age, foreigners, and prior tuberculosis history were significantly associated with MDR/RR-TB.

Conclusion: Rapid identification of rifampicin resistance targeting the high-risk populations, such as younger generations, foreign-born individuals, and previously treated patients are necessary for patient-centered care.

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2018-2021年韩国耐多药结核病和耐利福平单耐药结核病的临床概况：一项全国性横断面研究。

背景：本研究旨在确定大韩民国耐多药/耐利福平结核病（MDR/RR-TB）的临床特征：本研究旨在确定大韩民国耐多药/耐利福平结核病（MDR/RR-TB）的临床特征：从韩国结核病队列数据库中检索了2018年7月至2021年12月期间通报的结核病患者数据。根据对异烟肼的敏感性，MDR/RR-TB 进一步分类如下：(1）MDR-TB，（2）利福平单耐药结核病（RMR-TB），（3）RR-TB（如果对异烟肼的敏感性未知）。为确定与 MDR/RR-TB 相关的因素，进行了多变量逻辑回归分析：2018年至2021年间，在所有肺结核病例和已知药敏试验结果的肺结核病例中，MDR/RR-TB病例的比例为2.1%（502/24447）。在已知药敏试验结果的肺结核病例中，MDR/RR-TB 和 MDR-TB 病例的比例分别为 3.3%（502/15,071）和 1.9%（292/15,071）。在所有耐利福平病例中，31.7%（159/502）为RMR-TB，10.2%（51/502）为RR-TB。多变量逻辑回归分析表明，年龄较小、外国人和既往结核病史与 MDR/RR-TB 明显相关：结论：针对年轻一代、外国出生者和既往接受过治疗的患者等高危人群快速识别利福平耐药性是以患者为中心的医疗服务所必需的。

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