Association Between Proton Pump Inhibitor Use and Overactive Bladder Risk in Adults: A Cross-sectional Study.

IF 2.1 3区医学 Q2 UROLOGY & NEPHROLOGY Urology Pub Date : 2024-09-18 DOI:10.1016/j.urology.2024.09.015

Yuan-Zhuo Du, Jia-Hao Liu, Fu-Chun Zheng, Hong-Ji Hu, Qian-Xi Dong, Biao Guo, Jia-Lei Zhong, Ju Guo

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Abstract

Objective: To investigate the association between the use of proton pump inhibitors (PPIs) and overactive bladder (OAB) in adults.

Methods: This study adopts a cross-sectional approach to scrutinize data derived from the National Health and Nutrition Examination Survey (NHANES), spanning from 2007 to 2018. It employs multivariable logistic regression along with restricted cubic splines (RCS) to investigate the relationship between the use of PPI and the incidence of OAB. Additionally, through interaction and stratification analyses, the study delves into how specific factors may influence this correlation.

Results: A total of 24,458 adults participated in this study. Individuals using PPIs exhibited higher rates of nocturia, urge incontinence, and OAB compared to non-users. After full adjustment, PPI users had a significantly increased risk of developing OAB (OR=1.36, 95%CI: 1.17-1.60). Moreover, with each year of continued PPI usage, the frequency of OAB symptoms escalated by 3% (P = .01). Further examinations within various subgroups maintained a uniform direction in these effect estimates.

Conclusion: The findings of this research highlight a noteworthy positive link between the use of PPIs and the emergence of OAB among adults. Moreover, it was observed that an extended period of using PPIs correlates with a heightened likelihood of encountering OAB.

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成人使用质子泵抑制剂与膀胱过度活动症风险之间的关系：一项横断面研究

目的调查成人使用质子泵抑制剂（PPI）与膀胱过度活动症（OAB）之间的关联：本研究采用横断面方法，仔细研究了美国国家健康与营养调查（NHANES）中的数据，时间跨度为 2007 年至 2018 年。它采用多变量逻辑回归和限制性立方样条（RCS）来研究使用 PPI 与 OAB 发生率之间的关系。此外，通过交互和分层分析，该研究还深入探讨了特定因素可能如何影响这种相关性：共有 24,458 名成年人参与了这项研究。与不使用 PPIs 的人相比，使用 PPIs 的人夜尿、急迫性尿失禁和 OAB 的发生率更高。经过全面调整后，PPI 使用者患 OAB 的风险明显增加（OR = 1.36，95%CI：1.17-1.60）。此外，每持续使用一年 PPI，出现 OAB 症状的频率就会增加 3%（P=0.01）。在不同的亚组中进行的进一步研究表明，这些效应估计值的方向是一致的：这项研究的结果突出表明，在成人中使用 PPI 与 OAB 的出现之间存在值得注意的积极联系。此外，研究还发现，长期使用 PPIs 与出现 OAB 的可能性增加有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Urology 医学-泌尿学与肾脏学

CiteScore

3.30

自引率

9.50%

发文量

716

审稿时长

59 days

期刊介绍： Urology is a monthly, peer–reviewed journal primarily for urologists, residents, interns, nephrologists, and other specialists interested in urology The mission of Urology®, the "Gold Journal," is to provide practical, timely, and relevant clinical and basic science information to physicians and researchers practicing the art of urology worldwide. Urology® publishes original articles relating to adult and pediatric clinical urology as well as to clinical and basic science research. Topics in Urology® include pediatrics, surgical oncology, radiology, pathology, erectile dysfunction, infertility, incontinence, transplantation, endourology, andrology, female urology, reconstructive surgery, and medical oncology, as well as relevant basic science issues. Special features include rapid communication of important timely issues, surgeon''s workshops, interesting case reports, surgical techniques, clinical and basic science review articles, guest editorials, letters to the editor, book reviews, and historical articles in urology.