Particle Beam Radiobiology Status and Challenges: A PTCOG Radiobiology Subcommittee Report.

IF 2.1 Q3 ONCOLOGY International Journal of Particle Therapy Pub Date : 2024-08-08 eCollection Date: 2024-09-01 DOI:10.1016/j.ijpt.2024.100626
Reem Ahmad, Amelia Barcellini, Kilian Baumann, Malte Benje, Tamara Bender, Paloma Bragado, Alexandra Charalampopoulou, Reema Chowdhury, Anthony J Davis, Daniel K Ebner, John Eley, Jake A Kloeber, Robert W Mutter, Thomas Friedrich, Alvaro Gutierrez-Uzquiza, Alexander Helm, Marta Ibáñez-Moragues, Lorea Iturri, Jeannette Jansen, Miguel Ángel Morcillo, Daniel Puerta, Anggraeini Puspitasari Kokko, Daniel Sánchez-Parcerisa, Emanuele Scifoni, Takashi Shimokawa, Olga Sokol, Michael D Story, Juliette Thariat, Walter Tinganelli, Francesco Tommasino, Charlot Vandevoorde, Cläre von Neubeck
{"title":"Particle Beam Radiobiology Status and Challenges: A PTCOG Radiobiology Subcommittee Report.","authors":"Reem Ahmad, Amelia Barcellini, Kilian Baumann, Malte Benje, Tamara Bender, Paloma Bragado, Alexandra Charalampopoulou, Reema Chowdhury, Anthony J Davis, Daniel K Ebner, John Eley, Jake A Kloeber, Robert W Mutter, Thomas Friedrich, Alvaro Gutierrez-Uzquiza, Alexander Helm, Marta Ibáñez-Moragues, Lorea Iturri, Jeannette Jansen, Miguel Ángel Morcillo, Daniel Puerta, Anggraeini Puspitasari Kokko, Daniel Sánchez-Parcerisa, Emanuele Scifoni, Takashi Shimokawa, Olga Sokol, Michael D Story, Juliette Thariat, Walter Tinganelli, Francesco Tommasino, Charlot Vandevoorde, Cläre von Neubeck","doi":"10.1016/j.ijpt.2024.100626","DOIUrl":null,"url":null,"abstract":"<p><p>Particle therapy (PT) represents a significant advancement in cancer treatment, precisely targeting tumor cells while sparing surrounding healthy tissues thanks to the unique depth-dose profiles of the charged particles. Furthermore, their linear energy transfer and relative biological effectiveness enhance their capability to treat radioresistant tumors, including hypoxic ones. Over the years, extensive research has paved the way for PT's clinical application, and current efforts aim to refine its efficacy and precision, minimizing the toxicities. In this regard, radiobiology research is evolving toward integrating biotechnology to advance drug discovery and radiation therapy optimization. This shift from basic radiobiology to understanding the molecular mechanisms of PT aims to expand the therapeutic window through innovative dose delivery regimens and combined therapy approaches. This review, written by over 30 contributors from various countries, provides a comprehensive look at key research areas and new developments in PT radiobiology, emphasizing the innovations and techniques transforming the field, ranging from the radiobiology of new irradiation modalities to multimodal radiation therapy and modeling efforts. We highlight both advancements and knowledge gaps, with the aim of improving the understanding and application of PT in oncology.</p>","PeriodicalId":36923,"journal":{"name":"International Journal of Particle Therapy","volume":"13 ","pages":"100626"},"PeriodicalIF":2.1000,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11386331/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Particle Therapy","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1016/j.ijpt.2024.100626","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/9/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"ONCOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Particle therapy (PT) represents a significant advancement in cancer treatment, precisely targeting tumor cells while sparing surrounding healthy tissues thanks to the unique depth-dose profiles of the charged particles. Furthermore, their linear energy transfer and relative biological effectiveness enhance their capability to treat radioresistant tumors, including hypoxic ones. Over the years, extensive research has paved the way for PT's clinical application, and current efforts aim to refine its efficacy and precision, minimizing the toxicities. In this regard, radiobiology research is evolving toward integrating biotechnology to advance drug discovery and radiation therapy optimization. This shift from basic radiobiology to understanding the molecular mechanisms of PT aims to expand the therapeutic window through innovative dose delivery regimens and combined therapy approaches. This review, written by over 30 contributors from various countries, provides a comprehensive look at key research areas and new developments in PT radiobiology, emphasizing the innovations and techniques transforming the field, ranging from the radiobiology of new irradiation modalities to multimodal radiation therapy and modeling efforts. We highlight both advancements and knowledge gaps, with the aim of improving the understanding and application of PT in oncology.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
粒子束放射生物学的现状与挑战:PTCOG 放射生物学小组委员会报告。
粒子疗法(PT)是癌症治疗领域的一大进步,由于带电粒子独特的深度-剂量分布,它可以精确地靶向肿瘤细胞,同时保护周围的健康组织。此外,粒子的线性能量转移和相对生物效应增强了其治疗抗放射肿瘤(包括缺氧性肿瘤)的能力。多年来,广泛的研究为 PT 的临床应用铺平了道路,目前的目标是提高其疗效和精确度,最大限度地减少毒性。在这方面,放射生物学研究正朝着整合生物技术的方向发展,以推进药物发现和放射治疗优化。这种从基础放射生物学到了解 PT 分子机制的转变,旨在通过创新的剂量给药方案和联合治疗方法来扩大治疗窗口。本综述由来自不同国家的 30 多位撰稿人撰写,全面介绍了 PT 放射生物学的关键研究领域和新进展,强调了改变该领域的创新和技术,从新辐照模式的放射生物学到多模式放射治疗和建模工作。我们强调了研究进展和知识差距,旨在提高人们对肿瘤学中 PT 的理解和应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
International Journal of Particle Therapy
International Journal of Particle Therapy Medicine-Radiology, Nuclear Medicine and Imaging
CiteScore
3.70
自引率
5.90%
发文量
23
审稿时长
20 weeks
期刊最新文献
Impact of COVID-19 Pandemic on Carbon-Ion Radiation Therapy in Japan: A Japanese National Registry Study. Vaginal Mucosal Melanoma Cell Activation in Response to Photon or Carbon Ion Irradiation. Navigating a New Frontier: Evaluating Leadless Pacemakers in Proton Therapy. Cardiac Conduction System as an OAR in Radiation Therapy: Doses to SA/AV Nodes and Their Reduction. Value of Carbon-Ion Radiation Therapy for Breast Cancer.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1