Acquired isolated ACTH deficiency co-occurrence with breast cancer irrespective of paraneoplastic syndrome: coincidence or inevitability.

IF 0.7 Q4 ENDOCRINOLOGY & METABOLISM Endocrinology, Diabetes and Metabolism Case Reports Pub Date : 2024-09-19 Print Date: 2024-07-01 DOI:10.1530/EDM-23-0129
Shin Urai, Hironori Bando, Mei Nakatsuji, Masaaki Yamamoto, Hidenori Fukuoka, Genzo Iguchi, Wataru Ogawa
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Abstract

Summary: A 52-year-old female patient with breast cancer presented with a history of fatigue and malaise 1 year prior. She was diagnosed with isolated adrenocorticotropic hormone (ACTH) deficiency (IAD) on endocrinological examination. Her pituitary gland showed normal morphology. Paraneoplastic IAD associated with breast cancer was suspected; however, immunofluorescence staining revealed no ectopic ACTH or proopiomelanocortin expression in the tumor tissue. Subsequently, the patient was diagnosed with idiopathic acquired IAD concurrent with breast cancer, ruling out paraneoplastic syndrome. Although malignancy should be considered a potential cause of IAD, not all patients with concurrent IAD and malignancy necessarily develop paraneoplastic syndrome.

Learning points: Several adrenal insufficiency symptoms are similar to the nonspecific symptoms associated with malignancies, and therefore, the diagnosis of IAD remains challenging, especially in patients with cancer. When we encounter a case of IAD accompanied by a malignant tumor, it is important to suspect that paraneoplastic IAD, a novel clinical condition as secondary hypophysitis, may be the etiologic agent. Although malignant tumours should be considered a potential cause of IAD, not all patients with concurrent IAD and malignancy necessarily develop paraneoplastic autoimmune hypophysitis.

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获得性孤立促肾上腺皮质激素缺乏症与乳腺癌并发,与副肿瘤综合征无关:巧合还是必然。
摘要:一名 52 岁的女性乳腺癌患者在 1 年前曾出现乏力和不适症状。经内分泌检查,她被诊断为孤立性促肾上腺皮质激素(ACTH)缺乏症(IAD)。她的垂体形态正常。患者被怀疑患有与乳腺癌相关的副肿瘤性 IAD,但免疫荧光染色显示,肿瘤组织中没有异位促肾上腺皮质激素(ACTH)或原绒毛膜促皮质素(proopiomelanocortin)的表达。随后,患者被诊断为特发性获得性 IAD 并发乳腺癌,排除了副肿瘤综合征的可能性。虽然恶性肿瘤应被视为 IAD 的潜在病因,但并非所有同时患有 IAD 和恶性肿瘤的患者都一定会发展为副肿瘤综合征:学习要点:肾上腺功能不全的一些症状与恶性肿瘤相关的非特异性症状相似,因此,IAD 的诊断仍然具有挑战性,尤其是在癌症患者中。当我们遇到一例伴有恶性肿瘤的 IAD 病例时,必须怀疑继发性肾上腺皮质功能减退症这种新型临床症状可能是病因。虽然恶性肿瘤应被视为 IAD 的潜在病因,但并非所有同时患有 IAD 和恶性肿瘤的患者都一定会发展为副肿瘤性自身免疫性性腺功能减退症。
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来源期刊
CiteScore
1.50
自引率
0.00%
发文量
142
审稿时长
9 weeks
期刊介绍: Endocrinology, Diabetes & Metabolism Case Reports publishes case reports on common and rare conditions in all areas of clinical endocrinology, diabetes and metabolism. Articles should include clear learning points which readers can use to inform medical education or clinical practice. The types of cases of interest to Endocrinology, Diabetes & Metabolism Case Reports include: -Insight into disease pathogenesis or mechanism of therapy - Novel diagnostic procedure - Novel treatment - Unique/unexpected symptoms or presentations of a disease - New disease or syndrome: presentations/diagnosis/management - Unusual effects of medical treatment - Error in diagnosis/pitfalls and caveats
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