A novel internal target volume definition based on velocity and time of respiratory target motion for external beam radiotherapy.

IF 1.7 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Radiological Physics and Technology Pub Date : 2024-12-01 Epub Date: 2024-09-13 DOI:10.1007/s12194-024-00837-3
Masashi Yamanaka, Teiji Nishio, Kohei Iwabuchi, Hironori Nagata
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Abstract

This study aimed to develop a novel internal target volume (ITV) definition for respiratory motion targets, considering target motion velocity and time. The proposed ITV was evaluated in respiratory-gated radiotherapy. An ITV modified with target motion velocity and time (ITVvt) was defined as an ITV that includes a target motion based on target motion velocity and time. The target motion velocity was calculated using four-dimensional computed tomography (4DCT) images. The ITVvts were created from phantom and clinical 4DCT images. The phantom 4DCT images were acquired using a solid phantom that moved with a sinusoidal waveform (peak-to-peak amplitudes of 10 and 20 mm and cycles of 2-6 s). The clinical 4DCT images were obtained from eight lung cancer cases. In respiratory-gated radiotherapy, the ITVvt was compared with conventional ITVs for beam times of 0.5-2 s within the gating window. The conventional ITV was created by adding a uniform margin as the maximum motion within the gating window. In the phantom images, the maximum volume difference between the ITVvt and conventional ITV was -81.9%. In the clinical images, the maximum volume difference was -53.6%. Shorter respiratory cycles and longer BTs resulted in smaller ITVvt compared with the conventional ITV. Therefore, the proposed ITVvt plan could be used to reduce treatment volumes and doses to normal tissues.

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基于呼吸靶运动速度和时间的新型外照射放射治疗内靶体积定义。
本研究旨在为呼吸运动靶制定一种新的内部靶体积(ITV)定义,同时考虑到靶的运动速度和时间。在呼吸门控放射治疗中对所提出的 ITV 进行了评估。根据靶运动速度和时间修改的内靶体积(ITVvt)被定义为包括基于靶运动速度和时间的靶运动的内靶体积。靶移动速度通过四维计算机断层扫描(4DCT)图像计算得出。ITVvts 由模型和临床 4DCT 图像创建。模型 4DCT 图像是使用实体模型获取的,该模型以正弦波(峰-峰振幅分别为 10 毫米和 20 毫米,周期为 2-6 秒)运动。临床 4DCT 图像来自 8 个肺癌病例。在呼吸门控放射治疗中,ITVvt 与传统 ITV 进行了比较,在门控窗口内的射束时间为 0.5-2 秒。传统的 ITV 是通过在选通窗口内的最大运动中加入一个均匀的边缘来创建的。在模型图像中,ITVvt 和传统 ITV 之间的最大体积差为 -81.9%。在临床图像中,最大体积差为-53.6%。与传统的 ITV 相比,较短的呼吸周期和较长的 BT 会导致较小的 ITVvt。因此,建议的 ITVvt 方案可用于减少正常组织的治疗量和剂量。
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来源期刊
Radiological Physics and Technology
Radiological Physics and Technology RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-
CiteScore
3.00
自引率
12.50%
发文量
40
期刊介绍: The purpose of the journal Radiological Physics and Technology is to provide a forum for sharing new knowledge related to research and development in radiological science and technology, including medical physics and radiological technology in diagnostic radiology, nuclear medicine, and radiation therapy among many other radiological disciplines, as well as to contribute to progress and improvement in medical practice and patient health care.
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