Anna K Kloster, Luana N G Adami, Mariana Moysés-Oliveira, Helena Hachul, Monica L Andersen, Sergio Tufik
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引用次数: 0
Abstract
Objective: To establish an interaction network for genes related to premature ovarian insufficiency (POI) and insomnia, and to identify biological processes that connect POI to the physiological clock.
Methods: Previously reported lists of genes associated to POI and insomnia were contrasted and their intersection was used as input on protein-protein interaction analyses. POI-associated genes were contrasted with gene expression markers for neural circadian control and enriched pathways among their shared content were dissected.
Results: The functional network generated from the intersection between POI and insomnia gene lists pointed to the central nervous system as the most relevant cellular context for this connection. After identifying POI-associated genes that play a role in neural circadian patterns, we observed the disruption of pathways related to the hypothalamic-pituitary-gonadal axis as the major genetic link between ovarian function and circadian neural circuits.
Conclusions: These findings highlight neurological mechanisms that support the POI-insomnia interplay.
目的建立与卵巢早衰(POI)和失眠相关基因的相互作用网络,并确定连接卵巢早衰和生理时钟的生物过程:方法:将先前报道的与卵巢早衰和失眠相关的基因列表进行对比,并将其交叉点作为蛋白质-蛋白质相互作用分析的输入。将 POI 相关基因与神经昼夜节律控制的基因表达标记进行对比,并对其共享内容中的富集通路进行剖析:结果:从 POI 和失眠基因列表的交叉点生成的功能网络表明,中枢神经系统是这种联系最相关的细胞环境。在确定了在神经昼夜节律模式中发挥作用的 POI 相关基因后,我们观察到与下丘脑-垂体-性腺轴相关的通路中断是卵巢功能和昼夜节律神经回路之间的主要遗传联系:这些发现凸显了支持 POI-失眠相互作用的神经机制。