Associated factors of respiratory co-infection of COVID-19 and the impact of co-infection on SARS-CoV-2 viral load.

IF 1.4 4区 医学 Q4 INFECTIOUS DISEASES Journal of Infection in Developing Countries Pub Date : 2024-08-31 DOI:10.3855/jidc.18230
Xiaowen Hu, Feng Zhang, Jing Jia, Xueling Xin, Xiaoqi Dai, Liyan Dong, Zhaoguo Wang, Fachun Jiang
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Abstract

Introduction: Emerging evidence indicates that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infected individuals are at an increased risk for co-infections. This retrospective study aims to expand the knowledge of associated factors of respiratory co-infection in SARS-CoV-2 positivity.

Methodology: A retrospective study was conducted to recruit fifty-five patients with laboratory-confirmed SARS-CoV-2 positivity. We additionally tested 29 other respiratory pathogens using RT-PCR assay for the same specimens tested for laboratory-confirmed SARS-CoV-2. Both univariate and multivariate analysis were performed to identify independent factors for co-infection. Cox regression was conducted to detect the association between co-infection and viral load after controlling other related factors.

Results: Among all the fifty-five COVID-19 patients, the rate of co-infection with at least one other respiratory pathogen was 76.4% (42/55). The rate of bacterial co-infections was 83.3% (35/42), among which Streptococcus pneumonia was the most common co-infection. Over 70% of neutrophils proportion (OR: 4.563; 95% CI: 1.116-18.648) was an independently associated factor for bacterial co-infection, whereas fever (OR: 4.506; 95% CI: 1.044-19.441) and chest tightness (OR: 0.106; 95% CI: 0.015-0.743) for viral co-infection. The strongest promotion of SARS-CoV-2 viral decreasing load was detected from co-infection of only viruses (HR: 4.039; 95% CI: 1.238-13.177), and the weakest was found from co-infection of only bacteria (HR: 2.909; 95% CI: 1.308-6.472).

Conclusions: Various co-infections variously promote SARS-CoV-2 viral decreasing load. Timely identification of co-infections aggressively contributes to COVID-19 patient management.

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COVID-19 呼吸道合并感染的相关因素以及合并感染对 SARS-CoV-2 病毒载量的影响。
导言:新的证据表明,严重急性呼吸系统综合征冠状病毒 2(SARS-CoV-2)感染者合并感染的风险增加。这项回顾性研究旨在扩大对 SARS-CoV-2 阳性者呼吸道合并感染相关因素的了解:我们进行了一项回顾性研究,招募了 55 名经实验室确诊为 SARS-CoV-2 阳性的患者。此外,我们还使用 RT-PCR 法对实验室确诊为 SARS-CoV-2 阳性的同一标本中的 29 种其他呼吸道病原体进行了检测。我们进行了单变量和多变量分析,以确定合并感染的独立因素。在控制了其他相关因素后,进行了 Cox 回归以检测合并感染与病毒载量之间的关联:结果:在所有 55 名 COVID-19 患者中,至少合并感染一种其他呼吸道病原体的比例为 76.4%(42/55)。细菌合并感染率为 83.3%(35/42),其中肺炎链球菌是最常见的合并感染。中性粒细胞比例超过 70%(OR:4.563;95% CI:1.116-18.648)是细菌合并感染的独立相关因素,而发热(OR:4.506;95% CI:1.044-19.441)和胸闷(OR:0.106;95% CI:0.015-0.743)则是病毒合并感染的独立相关因素。仅病毒合并感染对 SARS-CoV-2 病毒载量下降的促进作用最强(HR:4.039;95% CI:1.238-13.177),仅细菌合并感染对 SARS-CoV-2 病毒载量下降的促进作用最弱(HR:2.909;95% CI:1.308-6.472):结论:各种合并感染可不同程度地促进 SARS-CoV-2 病毒载量的下降。结论:各种合并感染可不同程度地促进 SARS-CoV-2 病毒载量的下降,及时发现合并感染有助于积极管理 COVID-19 患者。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
3.70
自引率
5.30%
发文量
239
审稿时长
4-8 weeks
期刊介绍: The Journal of Infection in Developing Countries (JIDC) is an international journal, intended for the publication of scientific articles from Developing Countries by scientists from Developing Countries. JIDC is an independent, on-line publication with an international editorial board. JIDC is open access with no cost to view or download articles and reasonable cost for publication of research artcles, making JIDC easily availiable to scientists from resource restricted regions.
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