Immunohistochemical Expression of CXCL 10 in Vitiligo.

IF 1.1 4区 医学 Q4 DERMATOLOGY American Journal of Dermatopathology Pub Date : 2024-11-01 Epub Date: 2024-09-17 DOI:10.1097/DAD.0000000000002774
Asmaa Omar Abdelmonem, Amany Mohammad Abdel-Latif, Dareen Abdulaziz Mohamed, Ghada Fawzy Rezk Hassan
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Abstract

Background: Vitiligo is a skin disorder characterized by the loss of melanocytes from the epidermis. Cysteine x cysteine motif chemokine ligand 10 (CXCL10) is linked to the Th1 pattern and has been suggested as one of the most relevant chemokine axes that promote T-cell migration in different autoimmune and inflammatory processes. The aim of this study was to assess the immunohistochemical (IHC) expression of CXCL 10 in skin lesions of patients with vitiligo to explore its possible role in the pathogenesis of the disease.

Methods: In this prospective, case-control study, we examined biopsies from the lesional skin of 20 patients with vitiligo for IHC expression of CXCL 10: 10 patients presented with stable nonsegmental vitiligo (group A), 10 patients presented with active nonsegmental vitiligo (group B), and 10 apparently healthy volunteers were examined as controls (group C).

Results: Nine patients in group A had mild IHC expression of CXCL 10 (+1) and 1 patient had moderate expression (+2). In group B, 8 patients had strong expression of CXCL 10 (+3), and the remaining patients had moderate expression (+2). However, there was no expression of CXCL 10 in all skin specimens in the control group.

Conclusions: CXCL10 IHC expression was increased in vitiligo lesions indicating a possible role in the pathogenesis of disease. The expression was significantly increased in active vitiligo compared with stable vitiligo.

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白癜风中 CXCL 10 的免疫组化表达。
背景:白癜风是一种以表皮黑色素细胞脱失为特征的皮肤疾病。半胱氨酸 x 半胱氨酸基团趋化因子配体 10(CXCL10)与 Th1 模式有关,被认为是在不同自身免疫和炎症过程中促进 T 细胞迁移的最相关趋化因子轴之一。本研究旨在评估 CXCL 10 在白癜风患者皮损中的免疫组化(IHC)表达,以探讨其在疾病发病机制中可能扮演的角色:在这项前瞻性病例对照研究中,我们对20名白癜风患者的皮损活检组织进行了CXCL 10的IHC表达检测,其中包括10名稳定期非节段性白癜风患者(A组)、10名活动期非节段性白癜风患者(B组)和10名表面健康的志愿者作为对照组(C组):结果:A组中有9名患者CXCL 10轻度IHC表达(+1),1名患者中度表达(+2)。在 B 组中,8 名患者 CXCL 10 强表达(+3),其余患者中度表达(+2)。然而,对照组的所有皮肤标本中都没有 CXCL 10 的表达:结论:CXCL10 IHC 在白癜风皮损中的表达增加,表明它可能在疾病的发病机制中发挥作用。与稳定期白癜风相比,活动期白癜风的CXCL10表达明显增加。
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来源期刊
CiteScore
1.80
自引率
9.10%
发文量
453
审稿时长
3 months
期刊介绍: The American Journal of Dermatopathology offers outstanding coverage of the latest diagnostic approaches and laboratory techniques, as well as insights into contemporary social, legal, and ethical concerns. Each issue features review articles on clinical, technical, and basic science advances and illuminating, detailed case reports. With the The American Journal of Dermatopathology you''ll be able to: -Incorporate step-by-step coverage of new or difficult-to-diagnose conditions from their earliest histopathologic signs to confirmatory immunohistochemical and molecular studies. -Apply the latest basic science findings and clinical approaches to your work right away. -Tap into the skills and expertise of your peers and colleagues the world over peer-reviewed original articles, "Extraordinary cases reports", coverage of practical guidelines, and graphic presentations. -Expand your horizons through the Journal''s idea-generating forum for debating controversial issues and learning from preeminent researchers and clinicians
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