Merkel Cell Carcinoma Case Reports With Merkel Cell Polyomavirus Test and Review of the Literature.

IF 1.1 4区 医学 Q4 DERMATOLOGY American Journal of Dermatopathology Pub Date : 2024-11-01 Epub Date: 2024-09-17 DOI:10.1097/DAD.0000000000002837
Jingxiu Chai, Yichen Tang, Yuchong Chen, Yeqiang Liu
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Abstract

Abstract: Merkel cell carcinoma (MCC) is known as a rare and highly malignant neuroendocrine skin cancer and often occurs in the sun-exposed parts of the elderly individuals. In this article, we reported 2 cases of MCC and reviewed relative literature. Case 1 was a 91-year-old woman who presented with a half-year history of a brown nodule on the left temple. The histopathological and immunohistochemistry examination diagnosis was MCC with negative staining of Merkel cell polyomavirus large T antigen (CM2B4). Case 2 was a 76-year-old man with a nodule on his right buttock that gradually increased from approximately 3 mm to 1.5 cm in diameter in 1 month without pain. The biopsy diagnosis was MCC with positive staining of CM2B4. Previous studies have found that the genetic mutation and prognosis of polyomavirus-associated MCC (MCCP) and nonviral MCC (MCCN) are significantly different. Large T antigen plays a crucial role in Merkel cell polyomavirus (MCPyV) oncogenesis. Testing for the MCPyV at the onset of MCC is recommended, which is helpful in predicting the prognosis of patients.

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梅克尔细胞癌病例报告与梅克尔细胞多瘤病毒检测及文献综述。
摘要:众所周知,梅克尔细胞癌(MCC)是一种罕见的高度恶性神经内分泌皮肤癌,常发生于老年人暴露于阳光的部位。本文报告了 2 例 MCC 病例,并回顾了相关文献。病例 1 是一名 91 岁的女性,因左太阳穴上的棕色结节就诊半年。组织病理学和免疫组化检查诊断为 MCC,梅克尔细胞多瘤病毒大 T 抗原(CM2B4)染色阴性。病例 2 是一名 76 岁的男性,他的右臀部有一个结节,在 1 个月内直径从约 3 毫米逐渐增大到 1.5 厘米,没有疼痛感。活检诊断为 MCC,CM2B4 染色阳性。以往的研究发现,多瘤病毒相关 MCC(MCCP)和非病毒 MCC(MCCN)的基因突变和预后明显不同。大 T 抗原在梅克尔细胞多瘤病毒(MCPyV)致癌过程中起着至关重要的作用。建议在 MCC 发病时检测 MCPyV,这有助于预测患者的预后。
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来源期刊
CiteScore
1.80
自引率
9.10%
发文量
453
审稿时长
3 months
期刊介绍: The American Journal of Dermatopathology offers outstanding coverage of the latest diagnostic approaches and laboratory techniques, as well as insights into contemporary social, legal, and ethical concerns. Each issue features review articles on clinical, technical, and basic science advances and illuminating, detailed case reports. With the The American Journal of Dermatopathology you''ll be able to: -Incorporate step-by-step coverage of new or difficult-to-diagnose conditions from their earliest histopathologic signs to confirmatory immunohistochemical and molecular studies. -Apply the latest basic science findings and clinical approaches to your work right away. -Tap into the skills and expertise of your peers and colleagues the world over peer-reviewed original articles, "Extraordinary cases reports", coverage of practical guidelines, and graphic presentations. -Expand your horizons through the Journal''s idea-generating forum for debating controversial issues and learning from preeminent researchers and clinicians
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