The impact of Marfan syndrome and Ehlers-Danlos syndrome on the risk of penile fracture in patients between 18 and 45 years.

IF 3.3 3区医学 Q1 UROLOGY & NEPHROLOGY Journal of Sexual Medicine Pub Date : 2024-09-20 DOI:10.1093/jsxmed/qdae126

Kaushik P Kolanukuduru, Asher L Mandel, Rishabh K Simhal, Tamir N Sholklapper, Kelly Sun, Maria Poluch, Kerith R Wang, Yash B Shah, Paul H Chung

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Abstract

Background: Despite knowledge of the pathophysiology and clinical complications of connective tissue diseases (CTD), little is known regarding their impact on men's sexual health disorders.

Aim: To investigate the prevalence of penile fracture (PF) in patients with Ehlers-Danlos Syndrome (EDS) and Marfan syndrome (MFS) in comparison with disease-free controls between 18 and 45 years of age.

Methods: A multicenter, international, electronic health record network (TriNetX) was queried to identify adult male patients (between 18 and 45 years) with or without EDS and MFS between 1993 and 2023 using ICD-10 codes. The prevalence of PF was compared between patients with and without the diseases of interest. Prevalence ratios (PR) were generated with 95% confidence intervals.

Outcome: Prevalence of PF in patients with EDS and MFS when compared to disease-free controls.

Results: The number of patients with EDS, MFS, and control groups was 8060, 8642, and 20 184 547, respectively, with a mean age of 27.8 ± 7.58, 28.6 ± 7.4, and 31.6 ± 8.04 years. Men with EDS had a higher prevalence of PF (PR 30.18, 95% CI [17.08-53.19]; P < 0.0001). Similarly, men with MFS had a higher prevalence of PF (PR 23.4, 95% CI [12.6-43.7]; P < 0.0001).

Clinical implications: This study demonstrates an association between CTD and men's sexual health disorders. It may be important to counsel such men about the risks of PF.

Strengths and limitations: This is the largest study to date to demonstrate an association between CTD and men's sexual health disorders. While the large sample sizes in this study contribute to the robustness of the findings, the study is limited by the use of a claims-based dataset, which does not provide further details about disease course and complications, and the use of a univariate analysis only.

Conclusions: Patients with EDS and MFS are possibly at an elevated risk for PF. Due to the limitations of the TriNetX database, the analysis was limited to a univariate one, thus limiting the ability to control for confounders and limiting the generalizability of these findings. Further prospective research is needed to corroborate these findings.

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马凡氏综合征和埃勒斯-丹洛斯综合征对 18 至 45 岁患者阴茎骨折风险的影响。

背景：目的：调查埃勒斯-丹洛斯综合征（EDS）和马凡综合征（MFS）患者中阴茎骨折（PF）的患病率，并与18至45岁无病对照组进行比较：使用ICD-10编码查询了一个多中心、国际电子健康记录网络（TriNetX），以确定1993年至2023年间患有或未患有EDS和MFS的成年男性患者（18至45岁）。对患有和未患有相关疾病的患者的 PF 患病率进行了比较。得出患病率比（PR）及 95% 的置信区间：结果：与无疾病对照组相比，EDS 和 MFS 患者的 PF 患病率：EDS组、MFS组和对照组的患者人数分别为8060人、8642人和20 184 547人，平均年龄分别为（27.8±7.58）岁、（28.6±7.4）岁和（31.6±8.04）岁。患有 EDS 的男性 PF 患病率更高（PR 30.18，95% CI [17.08-53.19]；P 临床意义：本研究表明，CTD 与男性性健康障碍之间存在关联。向这些男性提供有关 PF 风险的咨询可能很重要：这是迄今为止证明 CTD 与男性性健康障碍之间存在关联的最大规模研究。虽然这项研究的样本量大，有助于提高研究结果的稳健性，但由于使用的是基于索赔的数据集，无法提供有关病程和并发症的更多细节，而且仅使用了单变量分析，因此研究受到了限制：结论：EDS 和 MFS 患者罹患 PF 的风险可能较高。由于TriNetX数据库的局限性，分析仅限于单变量分析，从而限制了控制混杂因素的能力，限制了这些研究结果的推广性。需要进一步的前瞻性研究来证实这些发现。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Sexual Medicine 医学-泌尿学与肾脏学

CiteScore

6.20

自引率

5.70%

发文量

826

审稿时长

2-4 weeks

期刊介绍： The Journal of Sexual Medicine publishes multidisciplinary basic science and clinical research to define and understand the scientific basis of male, female, and couples sexual function and dysfunction. As an official journal of the International Society for Sexual Medicine and the International Society for the Study of Women''s Sexual Health, it provides healthcare professionals in sexual medicine with essential educational content and promotes the exchange of scientific information generated from experimental and clinical research. The Journal of Sexual Medicine includes basic science and clinical research studies in the psychologic and biologic aspects of male, female, and couples sexual function and dysfunction, and highlights new observations and research, results with innovative treatments and all other topics relevant to clinical sexual medicine. The objective of The Journal of Sexual Medicine is to serve as an interdisciplinary forum to integrate the exchange among disciplines concerned with the whole field of human sexuality. The journal accomplishes this objective by publishing original articles, as well as other scientific and educational documents that support the mission of the International Society for Sexual Medicine.