{"title":"[Tau Positron Emission Tomography: Applications in Diagnosis and Prognosis of Various Diseases].","authors":"Keisuke Takahata, Manabu Kubota, Shin Kurose, Makoto Higuchi","doi":"10.11477/mf.1416202729","DOIUrl":null,"url":null,"abstract":"<p><p>Tau positron emission tomography (PET) is a neuroimaging technique that visualizes tau deposition using PET tracers that selectively bind to tau aggregates. Studies have reported the diagnostic and prognostic value of tau PET in Alzheimer's disease and other tauopathies. However, the binding profiles of tau PET drugs vary widely across tauopathies; therefore, an accurate understanding of the disease-specific characteristics is essential for interpretation of tau PET findings. In this review, we discuss the properties of tau-PET agents and their applications in various diseases.</p>","PeriodicalId":52507,"journal":{"name":"Brain and Nerve","volume":"76 9","pages":"1035-1044"},"PeriodicalIF":0.0000,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Brain and Nerve","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.11477/mf.1416202729","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
Abstract
Tau positron emission tomography (PET) is a neuroimaging technique that visualizes tau deposition using PET tracers that selectively bind to tau aggregates. Studies have reported the diagnostic and prognostic value of tau PET in Alzheimer's disease and other tauopathies. However, the binding profiles of tau PET drugs vary widely across tauopathies; therefore, an accurate understanding of the disease-specific characteristics is essential for interpretation of tau PET findings. In this review, we discuss the properties of tau-PET agents and their applications in various diseases.
tau正电子发射断层扫描（PET）是一种神经成像技术，它利用与tau聚集体选择性结合的PET示踪剂来观察tau沉积。研究报告显示，tau PET 对阿尔茨海默病和其他 tau 病具有诊断和预后价值。然而，tau PET药物的结合特征在不同的tau病症中差异很大；因此，准确了解疾病的特异性特征对于解释tau PET研究结果至关重要。在本综述中，我们将讨论tau-PET药物的特性及其在各种疾病中的应用。
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