Comparison of FGF-8, FGF-10, FGF-Receptor 2, Androgen Receptor, Estrogen Receptor-A and SS in Healthy and Hypospadiac Children.

IF 0.5 4区 医学 Q4 GENETICS & HEREDITY Balkan Journal of Medical Genetics Pub Date : 2024-09-06 eCollection Date: 2024-06-01 DOI:10.2478/bjmg-2024-0002
N Emaratpardaz, Z Turkyilmaz, R Karabulut, D Dayanir, C Kaya, Aae Sert, G Arkan, F A Ucaner, A Kapisiz, S Eryilmaz, A Atan, K Sonmez
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Abstract

In this study, we aimed to investigate the levels of Fibroblast Growth Factor-8 (FGF-8), FGF-10, FGF-Receptor-2 (FGFR-2), Androgen receptor (AR), Estrogen receptor alpha and beta (ER-α and ER-β) in the foreskins of children with and without hypospadias.

Methods: Samples from the foreskins of 20 children with hypospadias and 20 skin samples from children without hypospadias between the ages of 14 months and 12 years were taken during circumcision or hypospadias correction surgery for immunohistochemical (IHC) examination of these markers. In IHC examination, it was shown that ER-α, ER-β and AR receptors were more involved in the foreskin of children with hypospadias than in the fore-skin of without hypospadias children, and FGF-8, FGF-10 and FGFR-2 were lower (p<0.05). ER and AR uptake were higher in hypospadias tissue samples and FGF-8, FGF-10, and FGFR-2 uptakes were lower compared to without hypospadias children's tissue samples, and these factors were supported by affecting each other in the development of hypospadias. The limited number of studies on this subject in the literature and the contradictory results of the findings indicate that more research should be done on this subject in the future.

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健康和尿道下裂儿童的 FGF-8、FGF-10、FGF-受体 2、雄激素受体、雌激素受体-A 和 SS 的比较。
本研究旨在探讨尿道下裂患儿和非尿道下裂患儿包皮中成纤维细胞生长因子-8(FGF-8)、成纤维细胞生长因子-10、成纤维细胞生长因子受体-2(FGFR-2)、雄激素受体(AR)、雌激素受体α和β(ER-α和ER-β)的水平:方法:在进行包皮环切术或尿道下裂矫正术时,从 20 名尿道下裂患儿和 20 名非尿道下裂患儿(年龄在 14 个月至 12 岁之间)的包皮取样,对这些标记物进行免疫组化(IHC)检查。免疫组化检查结果显示,尿道下裂患儿前皮中ER-α、ER-β和AR受体的参与程度高于无尿道下裂患儿前皮中的ER-α、ER-β和AR受体,而FGF-8、FGF-10和FGFR-2的参与程度较低(p<0.05)。
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来源期刊
CiteScore
1.00
自引率
0.00%
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0
审稿时长
>12 weeks
期刊介绍: Balkan Journal of Medical Genetics is a journal in the English language for publication of articles involving all branches of medical genetics: human cytogenetics, molecular genetics, clinical genetics, immunogenetics, oncogenetics, pharmacogenetics, population genetics, genetic screening and diagnosis of monogenic and polygenic diseases, prenatal and preimplantation genetic diagnosis, genetic counselling, advances in treatment and prevention.
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