The role of circRNAs and miRNAs in drug resistance and targeted therapy responses in breast cancer.

IF 4.6 Q1 ONCOLOGY 癌症耐药(英文) Pub Date : 2024-08-20 eCollection Date: 2024-01-01 DOI:10.20517/cdr.2024.62
Meilan Zhang, Zhaokuan Zheng, Shouliang Wang, Ruihan Liu, Mengli Zhang, Zhiyun Guo, Hao Wang, Weige Tan
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Abstract

MicroRNAs (miRNAs) are small non-coding RNAs comprising 19-24 nucleotides that indirectly control gene expression. In contrast to other non-coding RNAs (ncRNAs), circular RNAs (circRNAs) are defined by their covalently closed loops, forming covalent bonds between the 3' and 5' ends. circRNAs regulate gene expression by interacting with miRNAs at transcriptional or post-transcriptional levels. Accordingly, circRNAs and miRNAs control many biological events related to cancer, including cell proliferation, metabolism, cell cycle, and apoptosis. Both circRNAs and miRNAs are involved in the pathogenesis of diseases, such as breast cancer. This review focuses on the latest discoveries on dysregulated circRNAs and miRNAs related to breast cancer, highlighting their potential as biomarkers for clinical diagnosis, prognosis, and chemotherapy response.

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circRNA 和 miRNA 在乳腺癌耐药性和靶向治疗反应中的作用。
微小 RNA(miRNA)是由 19-24 个核苷酸组成的小型非编码 RNA,可间接控制基因表达。与其他非编码 RNA(ncRNA)不同,环状 RNA(circRNA)的定义是其共价闭合环,在 3' 端和 5' 端之间形成共价键。因此,circRNAs 和 miRNAs 控制着许多与癌症有关的生物事件,包括细胞增殖、新陈代谢、细胞周期和细胞凋亡。circRNAs 和 miRNAs 都与乳腺癌等疾病的发病机制有关。本综述重点介绍与乳腺癌相关的循环RNA和miRNA失调的最新发现,强调它们作为临床诊断、预后和化疗反应生物标志物的潜力。
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