Feasibility and Safety of Food Containing Acanthopanax senticosus for Treating Patients with Cancer-Related Fatigue.

IF 1.1 Q4 HEALTH CARE SCIENCES & SERVICES Palliative medicine reports Pub Date : 2024-08-23 eCollection Date: 2024-01-01 DOI:10.1089/pmr.2024.0041

Yutaka Kawano, Nanae Watanabe, Masahiko Nishiyama, Tousei Ohmura, Hiroyoshi Mihara, Kaoru Ono, Maki Tanaka, Yasushi Sato, Tetsu Tomonari, Hidekatsu Takeda, Tetsuji Takayama

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Abstract

Background: Cancer-related fatigue (CRF) is a major obstacle to quality of life. Acanthopanax senticosus Harms (ASH) is available as a botanical adaptogen food worldwide.

Objective: This study aimed to assess the feasibility and safety of ASH in patients with CRF.

Methods: Fifteen patients with CRF consumed ASH drink for 28 days. The primary endpoint was the completion rate of the study, and the secondary endpoints were changes in brief fatigue inventory (BFI), oxidative stress markers, and adverse events.

Results: Seven patients successfully completed the study. Four patients who had BFI <5.5 at enrollment revealed a decrease in BFI. The biological antioxidant potential/diacron-reactive oxygen metabolites ratio, potential antioxidant capacity, was increased but not significant (p = 0.063). No adverse events attributable to ASH were observed.

Conclusions: Approximately 50% patients were successful in consuming ASH for 28 days. Patients with mild CRF showed improvement by using ASH. However, further investigations are needed to validate these findings.

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含刺五加的食品用于治疗癌症相关疲劳症患者的可行性和安全性

背景：癌症相关疲劳（CRF）是影响生活质量的主要障碍。Acanthopanax senticosus Harms（ASH）是一种植物性适应原食品，在世界各地均有销售：本研究旨在评估 ASH 在 CRF 患者中的可行性和安全性：方法：15 名 CRF 患者饮用 ASH 饮料 28 天。主要终点是研究完成率，次要终点是短暂疲劳量表（BFI）、氧化应激标记物和不良事件的变化：结果：七名患者成功完成了研究。结果：7 名患者成功完成了研究，其中 4 名患者的 BFI p = 0.063）。没有观察到可归因于 ASH 的不良事件：约 50% 的患者成功服用 ASH 28 天。轻度 CRF 患者服用 ASH 后病情有所改善。然而，还需要进一步的研究来验证这些发现。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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