Frailty assessment in geriatric radiation oncology.

Advances in cancer research Pub Date : 2024-01-01 Epub Date: 2024-08-23 DOI:10.1016/bs.acr.2024.07.003
Rahmi Atil Aksoy, Vildan Kaya
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引用次数: 0

Abstract

Older adults with cancer are at risk of over-treatment or under-treatment, and treatment decision-making is difficult due to both the complexity of adverse aging and under-representation in clinical trials. It is recommended to perform a frailty assessment before treatment decision-making. Although the importance of radiotherapy increases in geriatric oncology, there is less evidence base information on frailty assessment in radiation oncology than in medical/surgical oncology. The present literature review analyzed the available data regarding frailty assessment tools in geriatric radiation oncology. The predictive value of geriatric assessment on survival outcomes has been shown in many cancer subtypes treated with radiotherapy. Additionally, the Geriatric-8 score is the most evidenced screening tool in frailty assessment. However, researches are ongoing on the cut-off points of geriatric screening tools and which one is the best. Prospective randomized controlled trials are required for the integration of geriatric screening tools and geriatric assessment-driven interventions into geriatric radiation oncology practice.

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老年放射肿瘤学中的虚弱评估。
患有癌症的老年人面临着过度治疗或治疗不足的风险,而且由于不良衰老的复杂性和在临床试验中的代表性不足,治疗决策很难做出。建议在做出治疗决策前进行虚弱程度评估。虽然放射治疗在老年肿瘤学中的重要性日益增加,但与内外科肿瘤学相比,放射肿瘤学中有关虚弱评估的循证资料较少。本文献综述分析了有关老年放射肿瘤学中虚弱评估工具的现有数据。老年病学评估对放疗治疗的许多癌症亚型的生存结果都有预测价值。此外,老年医学-8 评分是最有证据的虚弱评估筛查工具。然而,关于老年病筛查工具的临界点以及哪种筛查工具最好的研究仍在进行中。需要进行前瞻性随机对照试验,以便将老年病筛查工具和以老年病评估为导向的干预措施纳入老年肿瘤放疗实践。
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