Low hemoglobin, even within the normal range, is associated with diabetic kidney disease

IF 4.6 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM Diabetes & metabolism Pub Date : 2024-09-18 DOI:10.1016/j.diabet.2024.101580
{"title":"Low hemoglobin, even within the normal range, is associated with diabetic kidney disease","authors":"","doi":"10.1016/j.diabet.2024.101580","DOIUrl":null,"url":null,"abstract":"<div><h3>Aim</h3><div>To investigate the association between hemoglobin (Hb) levels and incident diabetic kidney disease (DKD) in patients with type 2 diabetes.</div></div><div><h3>Methods</h3><div>This retrospective cohort study included 1,657 patients with diabetes, without DKD at baseline, recruited from six clinics affiliated with Lee's United Clinic in Taiwan. Demographic data and laboratory results were collected and analyzed. Participants were stratified into quartiles based on their baseline Hb levels. A subgroup analysis was conducted specifically for patients with normal Hb levels (men: Hb ≥ 120 g/l, women: Hb ≥ 110 g/l). Cox regression analysis assessed the relation between Hb levels and incident DKD, adjusting for relevant covariates.</div></div><div><h3>Results</h3><div>Among the initial cohort, 93 (5.6 %) had anemia at baseline. Over an average follow-up period of 5.7 ± 2.6 years, 594 patients (35.8 %) developed DKD. Cox regression analysis revealed that, after adjusting for multiple variables, compared with patients in the highest quartile of baseline Hb levels (Q4: Hb ≥ 154 g/l), the hazard of DKD was 1.6 times higher in the lowest quartile (Q1: Hb ≤ 130 g/l) HR [95 % CI] 1.58 [1.19;2.21] <em>P</em> &lt; 0.001. In patients with normal Hb levels, Cox regression analysis also revealed that compared to the highest quartile (Q’4, Hb ≥ 154 g/l) the hazard of developing DKD was 1.3 times higher in the lowest quartile (Q’1, Hb ≤ 132 g/l) HR [95 % CI ] 1.29 [1.08;1.72] <em>P</em> = 0.042.</div></div><div><h3>Conclusions</h3><div>Lower Hb is associated with incident DKD, even in patients with normal Hb levels, independent of other risk factors.</div></div>","PeriodicalId":11334,"journal":{"name":"Diabetes & metabolism","volume":null,"pages":null},"PeriodicalIF":4.6000,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Diabetes & metabolism","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1262363624000727","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
引用次数: 0

Abstract

Aim

To investigate the association between hemoglobin (Hb) levels and incident diabetic kidney disease (DKD) in patients with type 2 diabetes.

Methods

This retrospective cohort study included 1,657 patients with diabetes, without DKD at baseline, recruited from six clinics affiliated with Lee's United Clinic in Taiwan. Demographic data and laboratory results were collected and analyzed. Participants were stratified into quartiles based on their baseline Hb levels. A subgroup analysis was conducted specifically for patients with normal Hb levels (men: Hb ≥ 120 g/l, women: Hb ≥ 110 g/l). Cox regression analysis assessed the relation between Hb levels and incident DKD, adjusting for relevant covariates.

Results

Among the initial cohort, 93 (5.6 %) had anemia at baseline. Over an average follow-up period of 5.7 ± 2.6 years, 594 patients (35.8 %) developed DKD. Cox regression analysis revealed that, after adjusting for multiple variables, compared with patients in the highest quartile of baseline Hb levels (Q4: Hb ≥ 154 g/l), the hazard of DKD was 1.6 times higher in the lowest quartile (Q1: Hb ≤ 130 g/l) HR [95 % CI] 1.58 [1.19;2.21] P < 0.001. In patients with normal Hb levels, Cox regression analysis also revealed that compared to the highest quartile (Q’4, Hb ≥ 154 g/l) the hazard of developing DKD was 1.3 times higher in the lowest quartile (Q’1, Hb ≤ 132 g/l) HR [95 % CI ] 1.29 [1.08;1.72] P = 0.042.

Conclusions

Lower Hb is associated with incident DKD, even in patients with normal Hb levels, independent of other risk factors.
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
血红蛋白低,即使在正常范围内,也与糖尿病肾病有关。
目的:研究 2 型糖尿病患者的血红蛋白(Hb)水平与糖尿病肾病(DKD)之间的关系:这项回顾性队列研究纳入了从台湾李氏联合诊所下属六家诊所招募的 1,657 名糖尿病患者,这些患者基线时没有糖尿病肾病。研究人员收集并分析了人口统计学数据和实验室结果。根据基线血红蛋白水平将参与者分为四等分。专门针对 Hb 水平正常的患者(男性:Hb ≥ 120 克/升,女性:Hb ≥ 110 克/升)进行了亚组分析。Cox回归分析评估了Hb水平与DKD发病率之间的关系,并对相关协变量进行了调整:在初始队列中,93 人(5.6%)在基线时患有贫血。在平均 5.7 ± 2.6 年的随访期间,594 名患者(35.8%)出现了 DKD。Cox 回归分析显示,在对多种变量进行调整后,与基线 Hb 水平最高四分位数(Q4:Hb ≥ 154 g/l)的患者相比,最低四分位数(Q1:Hb ≤ 130 g/l)的 DKD 危险性高出 1.6 倍(HR [95% CI] 1.58 [1.19-2.21] P < 0.001)。在 Hb 水平正常的患者中,Cox 回归分析还显示,与最高四分位数(Q'4,Hb ≥ 154 g/l)相比,最低四分位数(Q'1,Hb ≤ 132 g/l)的 DKD 患病风险高出 1.3 倍:81.29 [1.08;1.72] P = 0.042.结论:即使是 Hb 水平正常的患者,较低的 Hb 也与 DKD 的发生有关,与其他风险因素无关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Diabetes & metabolism
Diabetes & metabolism 医学-内分泌学与代谢
CiteScore
12.00
自引率
4.20%
发文量
86
审稿时长
13 days
期刊介绍: A high quality scientific journal with an international readership Official publication of the SFD, Diabetes & Metabolism, publishes high-quality papers by leading teams, forming a close link between hospital and research units. Diabetes & Metabolism is published in English language and is indexed in all major databases with its impact factor constantly progressing. Diabetes & Metabolism contains original articles, short reports and comprehensive reviews.
期刊最新文献
Periodontitis adversely affects lipoprotein subfractions – results from the cohort study SHIP-TREND Perirenal fat and chronic kidney disease in type 2 diabetes: The mediation role of afferent arteriolar resistance Diuretics and risk of major adverse limb events in patients with type-2 diabetes: An observational retrospective study Sodium-glucose cotransporter-2 inhibitors versus dipeptidyl peptidase IV inhibitors and risk of dementia among patients with type 2 diabetes and comorbid mental disorders: A population-based cohort study Low hemoglobin, even within the normal range, is associated with diabetic kidney disease
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1