Analysis of suspected adverse reactions to food supplements containing beehive products: an update from the Italian Phytovigilance System.

Annali dell'Istituto superiore di sanita Pub Date : 2024-07-01 DOI:10.4415/ANN_24_03_08

Ilaria Ippoliti, Silvia Di Giacomo, Gabriela Mazzanti, Marco Silano, Francesca Menniti-Ippolito

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Abstract

Introduction: Beehive products are widely used in food supplements; however, their composition variability and allergenic components have raised some concerns. This work aims to provide information about the beehive products safety profile by evaluating the suspected adverse reactions (ARs).

Methods: The suspected report of ARs collected within the Italian Phytovigilance System (IPS) were evaluated. The clinical and demographic characteristics of the cases were described, and the causality assessment performed.

Results: 61 reports were analysed, mainly concerned women. Serious events were reported in 17 forms (28%). The ARs (n=116) referred to respiratory (25.0%), skin (24.1%), and gastrointestinal disorders (21.5%). Label warnings for atopic subjects were present only in 7 food supplements. The causality assessment was mostly probable (54.1%).

Conclusions: Present findings outline relevant information about the safety issues of beehive product consumption, especially in atopic or allergic subjects, and strengthen the importance of IPS to point out safety signals.

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含有蜂产品的食品补充剂的可疑不良反应分析：意大利植物警戒系统的最新情况。

导言：蜂产品被广泛应用于食品补充剂中，但其成分变化和过敏原成分引起了一些关注。这项工作旨在通过评估疑似不良反应（ARs），提供有关蜂产品安全性的信息：方法：对意大利植物警戒系统（IPS）收集的疑似 ARs 报告进行了评估。方法：对意大利植物警戒系统（IPS）中收集的疑似不良反应报告进行评估，描述病例的临床和人口特征，并进行因果关系评估：结果：分析了 61 份报告，主要涉及女性。有 17 份（28%）报告了严重事件。ARs（n=116）涉及呼吸系统疾病（25.0%）、皮肤疾病（24.1%）和胃肠道疾病（21.5%）。仅有 7 种食品补充剂针对特应性受试者发布了标签警告。因果关系评估大多为可能（54.1%）：目前的研究结果概述了蜂产品食用安全问题的相关信息，特别是对特应性或过敏性受试者，并加强了 IPS 指出安全信号的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Annali dell'Istituto superiore di sanita

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