From tradition to science: Possible mechanisms of ghee in supporting bone and joint health

IF 2.5 3区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Prostaglandins & other lipid mediators Pub Date : 2024-09-21 DOI:10.1016/j.prostaglandins.2024.106902

Maryam Falahatzadeh , Kianoosh Najafi , Kaveh Bashti

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Abstract

Ghee, a traditional form of clarified butter, has been used for centuries in Ayurvedic medicine for its numerous health benefits. Recent scientific studies have begun to elucidate the molecular mechanisms by which ghee may support bone and joint health. This review explores the bioactive components of ghee, including short-chain fatty acids (SCFAs), medium-chain fatty acids (MCFAs), and fat-soluble vitamins (A, D, E, K2), and their potential therapeutic effects on bone density, joint lubrication, and inflammation. SCFAs in ghee can potentially improve joint lubrication and reduce inflammation. MCFAs and conjugated linoleic acid (CLA) exhibit anti-inflammatory properties, modulating cytokine production and oxidative stress pathways. Vitamins D and K2 in ghee can play potentially crucial roles in calcium metabolism and bone mineralization, while vitamin A supports immune regulation and cartilage health. This review integrates traditional knowledge with contemporary scientific research, highlighting the potential of ghee as a complementary therapy for conditions such as osteoporosis and arthritis. By understanding the molecular mechanisms involved, future studies can focus on this field to shed a light on different effects of ghee on bone and joint health.

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从传统到科学：酥油支持骨骼和关节健康的可能机制。

酥油是一种传统形式的澄清黄油，几个世纪以来一直被阿育吠陀医学用于治疗各种健康问题。最近的科学研究已开始阐明酥油支持骨骼和关节健康的分子机制。本综述探讨了酥油中的生物活性成分，包括短链脂肪酸（SCFA）、中链脂肪酸（MCFA）和脂溶性维生素（A、D、E、K2），以及它们对骨密度、关节润滑和炎症的潜在治疗作用。酥油中的 SCFA 有可能改善关节润滑和减轻炎症。MCFAs和共轭亚油酸（CLA）具有抗炎特性，可调节细胞因子的产生和氧化应激途径。酥油中的维生素 D 和 K2 可在钙代谢和骨矿化中发挥潜在的关键作用，而维生素 A 则有助于免疫调节和软骨健康。这篇综述将传统知识与当代科学研究相结合，强调了酥油作为骨质疏松症和关节炎等疾病的辅助疗法的潜力。通过了解其中涉及的分子机制，未来的研究可以聚焦这一领域，揭示酥油对骨骼和关节健康的不同影响。

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来源期刊

Prostaglandins & other lipid mediators 生物-生化与分子生物学

CiteScore

5.80

自引率

3.40%

发文量

审稿时长

2 months

期刊介绍： Prostaglandins & Other Lipid Mediators is the original and foremost journal dealing with prostaglandins and related lipid mediator substances. It includes basic and clinical studies related to the pharmacology, physiology, pathology and biochemistry of lipid mediators. Prostaglandins & Other Lipid Mediators invites reports of original research, mini-reviews, reviews, and methods articles in the basic and clinical aspects of all areas of lipid mediator research: cell biology, developmental biology, genetics, molecular biology, chemistry, biochemistry, physiology, pharmacology, endocrinology, biology, the medical sciences, and epidemiology. Prostaglandins & Other Lipid Mediators also accepts proposals for special issue topics. The Editors will make every effort to advise authors of the decision on the submitted manuscript within 3-4 weeks of receipt.