[Vaccinations for emerging and re-emerging viral diseases].

Innere Medizin (Heidelberg, Germany) Pub Date : 2024-11-01 Epub Date: 2024-09-24 DOI:10.1007/s00108-024-01780-6
Hanna-Marie Weichel, Till Koch
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Abstract

Background: Emerging or re-emerging viral diseases have a pandemic potential and threaten global health. Vaccination is of crucial importance in the prevention of emerging and re-emerging viral diseases.

Objective: Description of the current status of vaccine development against Filoviridae, highly pathogenic coronaviruses, smallpox viruses, influenza viruses and arboviruses.

Material and methods: Focused literature search.

Results: The World Health Organization (WHO) regularly publishes a list of infectious diseases that are expected to pose a major threat to humanity as they are could potentially trigger new pandemics; however, in addition to these human-to-human transmissible diseases, some arboviruses also have pandemic potential. In recent years numerous new vaccines, some of which are highly effective, have been licensed against new and re-emerging viral diseases and other promising vaccine candidates are currently in development.

Conclusion: There are still gaps in the development of vaccines in the area of Filoviridae and highly pathogenic coronaviruses. Vaccinations against smallpox viruses have been available for a long time. Developing influenza vaccines against novel strains in a timely manner is a challenge and universal influenza vaccines could be a possible solution. Modern vaccines are available against the arboviruses dengue and Chikungunya fever.

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[为新出现和再次出现的病毒性疾病接种疫苗]。
背景:新出现或再次出现的病毒性疾病具有大流行的潜力,威胁着全球健康。疫苗接种对预防新发和再发病毒性疾病至关重要:描述针对丝状病毒科、高致病性冠状病毒、天花病毒、流感病毒和虫媒病毒的疫苗研发现状:材料和方法:重点文献检索:世界卫生组织(WHO)定期公布预计将对人类构成重大威胁的传染病名单,因为这些疾病有可能引发新的大流行;然而,除了这些人传人疾病外,一些虫媒病毒也有可能引发大流行。近年来,针对新发和复发病毒性疾病的许多新型疫苗(其中一些非常有效)已获得许可,其他有前景的候选疫苗目前也在开发之中:结论:在丝状病毒科和高致病性冠状病毒领域的疫苗开发仍存在差距。针对天花病毒的疫苗早已问世。及时开发针对新型菌株的流感疫苗是一项挑战,而通用流感疫苗可能是一种解决方案。目前已有针对登革热和基孔肯雅热虫媒病毒的现代疫苗。
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