Obesity increases the risk of hepatic fibrosis in young adults with type 2 diabetes mellitus: the need to screen

IF 4.2 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM Obesity Pub Date : 2024-09-24 DOI:10.1002/oby.24130
Anu Sharma, Eddison Godina Leiva, Srilaxmi Kalavalapalli, Romina Lomonaco, Stephen A. Marangi, Enrique Valdez Saenz, Maria A. Gonzalez, Andrea Ortiz Rocha, Nathaly Cuervo Pardo, Jens Rosenberg, Pierre Bedossa, Fernando Bril, Diana Barb, Kenneth Cusi
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Abstract

Objective

The objective of this study was to determine the prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) in young compared with older adults.

Methods

Individuals (n = 1420) with (63%) and without type 2 diabetes mellitus (T2D; 37%) who attended internal medicine clinics and did not have a known history of MASLD underwent laboratory evaluation and transient elastography to assess for hepatic steatosis and fibrosis. Magnetic resonance elastography and liver biopsy were recommended when indicated.

Results

A total of 243 participants were ages <45 years, and 1177 were ages ≥45 years. Obesity, T2D, and metabolic syndrome were highly prevalent in young adults. Frequencies of steatosis and fibrosis were high in young adults (50.2% and 7.5% vs. older adults 52.7% and 9.9%, respectively) and were significantly higher in those with both obesity and T2D (71.1% and 15.7%, respectively; p < 0.01). In young adults, T2D and obesity were the strongest risk factors for hepatic fibrosis (odds ratios 4.33 [95% CI: 1.37–13.68] and 1.16 [95% CI: 1.07–1.25], respectively; p < 0.05).

Conclusions

There is a high prevalence of clinically significant hepatic fibrosis in young adults with cardiometabolic risk factors. Up to one in seven young adults with obesity and T2D had clinically significant hepatic fibrosis on elastography. This highlights the need to screen young adults with cardiometabolic risk factors for MASLD for early detection and intervention.

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肥胖会增加 2 型糖尿病青壮年患者肝纤维化的风险:需要进行筛查。
研究目的本研究旨在确定代谢功能障碍相关性脂肪性肝病(MASLD)在年轻人与老年人中的患病率:在内科门诊就诊的患有(63%)和未患有(37%)2型糖尿病(T2D)且没有已知MASLD病史的个体(n = 1420)接受了实验室评估和瞬态弹性成像检查,以评估肝脏脂肪变性和纤维化情况。如有必要,建议进行磁共振弹性成像和肝活检:结果:共有 243 人符合年龄要求:在具有心脏代谢风险因素的年轻人中,具有临床意义的肝纤维化发病率很高。每七名患有肥胖症和糖尿病的年轻人中就有一人在弹性成像检查中发现有临床意义的肝纤维化。这突出表明,有必要对具有心脏代谢风险因素的年轻人进行MASLD筛查,以便及早发现和干预。
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来源期刊
Obesity
Obesity 医学-内分泌学与代谢
CiteScore
11.70
自引率
1.40%
发文量
261
审稿时长
2-4 weeks
期刊介绍: Obesity is the official journal of The Obesity Society and is the premier source of information for increasing knowledge, fostering translational research from basic to population science, and promoting better treatment for people with obesity. Obesity publishes important peer-reviewed research and cutting-edge reviews, commentaries, and public health and medical developments.
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Issue Information Poster Abstracts Oral Abstracts Issue Information Cardiometabolic characteristics of weight cycling: results from a mid-South regional comprehensive health care system
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