Aoqun Song , Yunting Wang , Cuifang Liu , Juan Yu , Zixu Zhang , Liting Lan , Haiyan Lin , Jicheng Zhao , Guohong Li
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引用次数: 0
Abstract
During the development of eukaryote, faithful inheritance of chromatin states is central to the maintenance of cell fate. DNA replication poses a significant challenge for chromatin state inheritance because every nucleosome in the genome is disrupted as the replication fork passes. It has been found that many factors including DNA polymerases, histone chaperones, as well as, RNA Pol II and histone modifying enzymes coordinate spatially and temporally to maintain the epigenome during this progress. In this review, we provide a summary of the detailed mechanisms of replication-coupled nucleosome assembly and post-replication chromatin maturation, highlight the inheritance of chromatin states and epigenome during these processes, and discuss the future directions and challenges in this field.
在真核生物的发育过程中，染色质状态的忠实遗传是维持细胞命运的核心。DNA 复制给染色质状态的遗传带来了巨大挑战，因为复制叉经过时，基因组中的每个核小体都会被打乱。研究发现，在这一过程中，包括 DNA 聚合酶、组蛋白伴侣以及 RNA Pol II 和组蛋白修饰酶在内的许多因素在空间和时间上相互协调，以维持表观基因组。在这篇综述中，我们总结了复制耦合核小体组装和复制后染色质成熟的详细机制，强调了这些过程中染色质状态和表观基因组的遗传，并讨论了这一领域的未来方向和挑战。
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