Development and characterization of caffeine-loaded nanoliposomes decorated by cationic amylose and cationic amylose- menthol inclusion complex coatings; a novel oral co-delivery system

IF 8.5 1区农林科学 Q1 CHEMISTRY, APPLIED Food Chemistry Pub Date : 2024-09-18 DOI:10.1016/j.foodchem.2024.141350

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Abstract

Nanoliposomes (NLPs) have evolved as compelling carriers for loading bioactive compounds. To improve the phospholipid bilayer membrane stability, caffeine-loaded NLPs were coated with cationic amylose (CA) and CA–menthol inclusion complexes (CAMICs). The zeta potential results indicated an electrostatic attraction between CA and the negatively charged NLPs. Observations from dynamic light scattering, atomic force microscopy, and Fourier transform infrared spectroscopy demonstrated the efficient deposition of both CA and CAMICs onto the surface of NLPs without altering their spherical shape. Raman spectra and X-ray diffraction patterns indicated that both CA and CAMICs can decrease membrane fluidity and enhance lipid packing laterally. Additional assessment through thermogravimetric analysis revealed that the coating of NLPs, particularly with CAMICs, protected caffeine against thermal degradation. These coated NLPs show promise for formulation advancement, facilitating the simultaneous delivery of functional compounds.

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由阳离子直链淀粉和阳离子直链淀粉-薄荷醇包合物涂层装饰的载咖啡因纳米脂质体的开发与表征；一种新型口服联合给药系统

纳米脂质体（NLPs）已发展成为装载生物活性化合物的理想载体。为了提高磷脂双分子层膜的稳定性，用阳离子直链淀粉（CA）和CA-薄荷醇包合物（CAMIC）包覆了负载咖啡因的NLP。zeta 电位结果表明，CA 与带负电荷的 NLP 之间存在静电吸引。动态光散射、原子力显微镜和傅立叶变换红外光谱的观察结果表明，CA 和 CAMIC 都能有效地沉积在 NLP 表面，而不会改变其球形形状。拉曼光谱和 X 射线衍射图样表明，CA 和 CAMIC 都能降低膜的流动性，增强脂质的横向堆积。通过热重分析进行的其他评估表明，包覆 NLP（尤其是 CAMIC）可保护咖啡因不受热降解的影响。这些涂布的 NLP 有望推动配方的发展，促进功能化合物的同时输送。

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来源期刊

Food Chemistry 工程技术-食品科技

CiteScore

16.30

自引率

10.20%

发文量

3130

审稿时长

122 days

期刊介绍： Food Chemistry publishes original research papers dealing with the advancement of the chemistry and biochemistry of foods or the analytical methods/ approach used. All papers should focus on the novelty of the research carried out.