Myrtenol-Loaded Fatty Acid Nanocarriers Protect Rat Brains Against Ischemia–Reperfusion Injury: Antioxidant and Anti-Inflammatory Effects

IF 3.2 4区 医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Chemical Biology & Drug Design Pub Date : 2024-09-24 DOI:10.1111/cbdd.14633
Shima Karimi Afshar, Farzaneh Rostamzadeh, Mohammad Reza Bigdeli, Fatemeh Mortazavi Moghadam
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Abstract

This research investigated the preventive effects of myrtenol (MYR), fatty acid nanocarriers (FANC), and myrtenol-loaded FANC (MYR + FANC) on neurological disturbance, stroke volume, the levels of malondialdehyde (MDA), superoxide dismutase (SOD), and tumor necrosis factor-alpha (TNF-α) in the brain with ischemiareperfusion injuries induced by middle cerebral artery occlusion (MCAO) in rats. Seventy two Wistar male rats were divided into six main groups. The groups were sham, ischemiareperfusion group (MACO), MACO-MYR (50 mg/kg), MACO-FANC (50 and 100 mg/kg), and MACO-MYR + FANC (50 mg/kg). Stroke volume, neurological deficit scores, and the brain levels of MDA, SOD, and TNF-α were examined with TTC staining, observation, and ELISA, respectively. Pretreatment with MYR, FANC (100 mg/kg), and MYR + FANC reduced the neurological deficit score and cerebral infarction volume. MYR, FANC (100 mg/kg), and MYR + FANC pretreatment increased and decreased brain SOD and MDA levels compared to MACO group, respectively. The TNF-α level decreased in the MYR + FANC group compared to MCAO and MCAO-MYR groups in the brain. The use of FANC (100 mg/kg), MYR, and MYR + FANC has protective effects against oxidative stress and ischemiareperfusion injury. FANC probably improve the bioavailability of MYR, as MYR+ FANC had more therapeutic effects on the reduction of ischemia–reperfusion injuries, inflammation, and oxidative stress.

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肉豆蔻醇负载脂肪酸纳米载体保护大鼠大脑免受缺血再灌注损伤:抗氧化和抗炎作用
本研究探讨了麦芽酚(MYR)、脂肪酸纳米载体(FANC)和负载麦芽酚的FANC(MYR + FANC)对大脑中动脉闭塞(MCAO)诱导的脑缺血再灌注损伤大鼠的神经功能紊乱、卒中量、丙二醛(MDA)、超氧化物歧化酶(SOD)和肿瘤坏死因子-α(TNF-α)水平的预防作用。72只Wistar雄性大鼠被分为六个主要组别。分别为假组、缺血再灌注组(MACO)、MACO-MYR(50 毫克/千克)、MACO-FANC(50 和 100 毫克/千克)以及 MACO-MYR + FANC(50 毫克/千克)。分别用 TTC 染色法、观察法和酶联免疫吸附法检测脑卒中容量、神经功能缺损评分以及脑内 MDA、SOD 和 TNF-α 的水平。MYR、FANC(100 mg/kg)和MYR + FANC的预处理降低了神经功能缺损评分和脑梗死体积。与MACO组相比,MYR、FANC(100 mg/kg)和MYR + FANC预处理分别提高和降低了脑SOD和MDA水平。与 MCAO 组和 MCAO-MYR 组相比,MYR + FANC 组脑中 TNF-α 水平下降。使用 FANC(100 毫克/千克)、MYR 和 MYR + FANC 对氧化应激和缺血再灌注损伤有保护作用。FANC 可能提高了 MYR 的生物利用率,因为 MYR+ FANC 对减轻缺血再灌注损伤、炎症和氧化应激有更多的治疗效果。
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来源期刊
Chemical Biology & Drug Design
Chemical Biology & Drug Design 医学-生化与分子生物学
CiteScore
5.10
自引率
3.30%
发文量
164
审稿时长
4.4 months
期刊介绍: Chemical Biology & Drug Design is a peer-reviewed scientific journal that is dedicated to the advancement of innovative science, technology and medicine with a focus on the multidisciplinary fields of chemical biology and drug design. It is the aim of Chemical Biology & Drug Design to capture significant research and drug discovery that highlights new concepts, insight and new findings within the scope of chemical biology and drug design.
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