A quinine squaramide catalyzed enantioselective [4 + 2] cycloaddition between ortho-hydroxyphenyl para-quinone methide and γ-butenolides for preparation of chiral 3, 4-dihydrocoumarins
Jing-Liang Yu , Su-Fan Gao , Chun-Jun Zhu , Wen-Sheng Li , Li-Xin Wang
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引用次数: 0
Abstract
A quinine-squaramide catalyzed enantioselective inverse-electron-demand hetero-Diels–Alder reaction between γ-butenolides and ortho-hydroxyphenyl p-QMs has been disclosed. A wide range of chiral 3, 4-dihydrocoumarins frameworks with two adjacent stereogenic centers have been directly and concisely prepared in excellent results (up to 94 % yield, 99:1 dr, 98:2 er) under mild conditions.
期刊介绍：
Tetrahedron Letters provides maximum dissemination of outstanding developments in organic chemistry. The journal is published weekly and covers developments in techniques, structures, methods and conclusions in experimental and theoretical organic chemistry. Rapid publication of timely and significant research results enables researchers from all over the world to transmit quickly their new contributions to large, international audiences.
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