Infection-responsive polysaccharide-based drug-loaded nano-assembly for dual-modal treatment against drug-resistant bacterial lung infection (3/2024)

Abstract

In this article number 10.1002/bmm2.12120, a kind of infection-responsive drug-loaded nano-assembly, STQ12, was developed by the electrostatic interaction between negatively charged polysaccharide and positively charged quaternized ammonium salt polymer. STQ12 could penetrate the mucus layer rapidly and reach the acidic microenvironment at the infected site, releasing the loaded drug and QPEI-C6 to realize combined anti-infection therapy against multi-drug resistant bacteria.