Intercellular adhesion molecule-1 (ICAM-1): From molecular functions to clinical applications in cancer investigation

IF 9.7 1区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Biochimica et biophysica acta. Reviews on cancer Pub Date : 2024-09-22 DOI:10.1016/j.bbcan.2024.189187
Wen-Jing Qian , Jin-Shan Yan , Xiao-Yu Gang , Lu Xu , Sha Shi , Xin Li , Fang-Jian Na , Lu-tong Cai , He-Ming Li , Ming-Fang Zhao
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Abstract

Intercellular adhesion molecule-1 (ICAM-1) is a versatile molecule that plays a critical role in various physiological and pathological processes, particularly in tumor development where its impact is bidirectional. On the one hand, it augments the immune response by promoting immune cell migration, infiltration, and the formation of immunological synapses, thus facilitating potent antitumor effects. Simultaneously, it contributes to tumor immune evasion and influences metastasis by mediating transendothelial migration (TEM), epithelial-to-mesenchymal transition (EMT), and epigenetic modification of tumor cells. Despite its significant potential, the full clinical utility of ICAM-1 has yet to be fully realized. In this review, we thoroughly examine recent advancements in understanding the role of ICAM-1 in tumor development, its relevance in predicting therapeutic efficacy and prognosis, as well as the progress in clinical translational research on anti-ICAM-1-based therapies, encompassing including monoclonal antibodies, immunotherapy, antibody-drug conjugate (ADC), and conventional treatments. By shedding light on these innovative strategies, we aim to underscore ICAM-1's significance as a valuable and multifaceted target for cancer treatment, igniting enthusiasm for further research and facilitating translation into clinical applications.
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细胞间粘附分子-1 (ICAM-1):从分子功能到癌症研究中的临床应用
细胞间粘附分子-1(ICAM-1)是一种多功能分子,在各种生理和病理过程中发挥着关键作用,尤其是在肿瘤发生发展过程中,它的影响是双向的。一方面,它通过促进免疫细胞迁移、浸润和免疫突触的形成来增强免疫反应,从而促进有效的抗肿瘤作用。同时,它还通过介导肿瘤细胞的跨内皮迁移(TEM)、上皮细胞向间质转化(EMT)和表观遗传学改变,促进肿瘤免疫逃避并影响肿瘤转移。尽管 ICAM-1 具有巨大的潜力,但其临床用途尚未得到充分发挥。在这篇综述中,我们将深入探讨最近在了解 ICAM-1 在肿瘤发生发展中的作用、其在预测疗效和预后方面的相关性以及基于抗 ICAM-1 疗法的临床转化研究进展方面取得的进展,包括单克隆抗体、免疫疗法、抗体药物结合物 (ADC) 和传统疗法。通过揭示这些创新策略,我们旨在强调 ICAM-1 作为癌症治疗的一个有价值的、多方面的靶点的意义,点燃进一步研究的热情,促进转化为临床应用。
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来源期刊
Biochimica et biophysica acta. Reviews on cancer
Biochimica et biophysica acta. Reviews on cancer 医学-生化与分子生物学
CiteScore
17.20
自引率
0.00%
发文量
138
审稿时长
33 days
期刊介绍: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer encompasses the entirety of cancer biology and biochemistry, emphasizing oncogenes and tumor suppressor genes, growth-related cell cycle control signaling, carcinogenesis mechanisms, cell transformation, immunologic control mechanisms, genetics of human (mammalian) cancer, control of cell proliferation, genetic and molecular control of organismic development, rational anti-tumor drug design. It publishes mini-reviews and full reviews.
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