New AAV vector targets glomerular endothelial cells

IF 28.6 1区 医学 Q1 UROLOGY & NEPHROLOGY Nature Reviews Nephrology Pub Date : 2024-09-27 DOI:10.1038/s41581-024-00898-y
Monica Wang
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以肾小球内皮细胞为靶标的新型 AAV 向量
基因疗法在临床上的应用越来越广泛,但特异性地输送到肾脏细胞仍然是肾脏病学广泛应用的一个重要障碍。为了测试AAV2-GEC的治疗潜力,研究人员用它携带了编码IdeS的基因,IdeS是化脓性链球菌蛋白酶,能裂解IgG重链。在注射抗肾小球基底膜(GBM)羊血清诱导的肾小球肾炎小鼠模型中,诱导一天后用AAV2-GEC-IdeS治疗具有肾保护作用。与注射了不含 IdeS 的 AAV2-GEC 的对照组小鼠相比,接受治疗的小鼠白蛋白尿较少且持续时间较短,小鼠和绵羊 IgG 在 GBM 上的沉积也较弱。
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来源期刊
Nature Reviews Nephrology
Nature Reviews Nephrology 医学-泌尿学与肾脏学
CiteScore
39.00
自引率
1.20%
发文量
127
审稿时长
6-12 weeks
期刊介绍: Nature Reviews Nephrology aims to be the premier source of reviews and commentaries for the scientific communities it serves. It strives to publish authoritative, accessible articles. Articles are enhanced with clearly understandable figures, tables, and other display items. Nature Reviews Nephrology publishes Research Highlights, News & Views, Comments, Reviews, Perspectives, and Consensus Statements. The content is relevant to nephrologists and basic science researchers. The broad scope of the journal ensures that the work reaches the widest possible audience.
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