Neuroscience of cancer: Research progress and emerging of the field

Ibrain Pub Date : 2024-08-14 DOI:10.1002/ibra.12172
Issam AbuQeis, Yu Zou, Ying-Chun Ba, Abeer A. Teeti
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Abstract

Cancer cells immediately expand and penetrate adjoining tissues, as opposed to metastasis, that is the spread of cancer cells through the circulatory or lymphatic systems to more distant places via the invasion process. We found that a lack of studies discussed tumor development with the nervous system, by the aspects of cancer-tissue invasion (biological) and chemical modulation of growth that cascades by releasing neural-related factors from the nerve endings via chemical substances known as neurotransmitters. In this review, we aimed to carefully demonstrate and describe the cancer invasion and interaction with the nervous system, as well as reveal the research progress and the emerging neuroscience of cancer. An initial set of 160 references underwent systematic review and summarization. Through a meticulous screening process, these data were refined, ultimately leading to the inclusion of 98 studies that adhered to predetermined criteria. The outcomes show that one formidable challenge in the realm of cancer lies in its intrinsic heterogeneity and remarkable capacity for rapid adaptation. Despite advancements in genomics and precision medicine, there is still a need to identify new molecular targets. Considering cancer within its molecular and cellular environment, including neural components, is crucial for addressing this challenge. In conclusion, this review provides good referential data for direct, indirect, biological, and chemical interaction for nerve tissue–tumor interaction, suggesting the establishment of new therapy techniques and mechanisms by controlling and modifying neuron networks that supply signals to tumors.

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癌症神经科学:研究进展和新兴领域
与癌细胞通过循环系统或淋巴系统扩散到更远的地方的入侵过程不同,癌细胞会立即扩展并渗透到邻近组织。我们发现,通过癌症-组织侵袭(生物学)和化学调控生长(通过称为神经递质的化学物质从神经末梢释放神经相关因子,从而实现级联反应)等方面讨论肿瘤发生与神经系统关系的研究并不多见。在这篇综述中,我们旨在仔细论证和描述癌症的侵袭以及与神经系统的相互作用,并揭示癌症的研究进展和新兴的神经科学。我们对最初的 160 篇参考文献进行了系统回顾和总结。通过细致的筛选过程,这些数据得到了完善,最终纳入了 98 项符合预定标准的研究。研究结果表明,癌症领域的一个严峻挑战在于其固有的异质性和非凡的快速适应能力。尽管基因组学和精准医疗取得了进展,但仍需要确定新的分子靶点。将癌症置于其分子和细胞环境(包括神经成分)中考虑,对于应对这一挑战至关重要。总之,这篇综述为神经组织与肿瘤之间的直接、间接、生物和化学相互作用提供了很好的参考数据,建议通过控制和改变向肿瘤提供信号的神经元网络来建立新的治疗技术和机制。
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