Microfluidic antisolvent crystallization for chiral symmetry breaking†

IF 6.1 2区 工程技术 Q1 BIOCHEMICAL RESEARCH METHODS Lab on a Chip Pub Date : 2024-09-30 DOI:10.1039/D4LC00658E
Jiye Jang, Gerard Coquerel, Tae Seok Seo, Woo-Sik Kim and Bum Jun Park
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Abstract

We report on the use of a microfluidic antisolvent crystallization method to investigate the effect of solution volume on the chiral symmetry breaking (CSB) phenomena of enantiomeric sodium chlorate crystals. The utilization of a microfluidic device is capable of periodically producing emulsion droplets of uniform size and facilitates the quantitative analysis and visualization of crystallization phenomena occurring within the individual emulsions immersed in an oil continuous medium (i.e., dodecane). To promote nucleation and crystallization, a small amount of an antisolvent (i.e., ethanol) is introduced into the continuous phase. We observe that 100% CSB occurs within a certain critical emulsion volume. Beyond this critical volume, the probability of forming two different enantiomeric crystal particles increases. This solution volume-dependent CSB phenomenon can be attributed to the rapid depletion of surrounding molecules by spontaneous crystal growth after the formation of the initial nucleus within the critical volume, thereby suppressing further primary nucleation.

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用于手性对称性破缺的微流控反溶剂结晶技术
我们报告了利用微流体反溶剂结晶法研究溶液体积对氯酸钠对映体晶体手性对称性破坏(CSB)现象的影响。微流控装置能够周期性地产生大小均匀的乳液液滴,便于定量分析和观察浸没在连续油介质(即十二烷)中的单个乳液的结晶现象。为了促进成核和结晶,在连续相中引入了少量的反溶剂(如乙醇)。我们观察到,在一定临界乳液体积内会出现 100% 的 CSB。超过这个临界体积,形成两种不同对映体晶体颗粒的概率就会增加。这种取决于溶液体积的 CSB 现象可归因于临界体积内初始晶核形成后,周围分子的自发晶体生长迅速耗尽,从而抑制了进一步的原生晶核形成。
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来源期刊
Lab on a Chip
Lab on a Chip 工程技术-化学综合
CiteScore
11.10
自引率
8.20%
发文量
434
审稿时长
2.6 months
期刊介绍: Lab on a Chip is the premiere journal that publishes cutting-edge research in the field of miniaturization. By their very nature, microfluidic/nanofluidic/miniaturized systems are at the intersection of disciplines, spanning fundamental research to high-end application, which is reflected by the broad readership of the journal. Lab on a Chip publishes two types of papers on original research: full-length research papers and communications. Papers should demonstrate innovations, which can come from technical advancements or applications addressing pressing needs in globally important areas. The journal also publishes Comments, Reviews, and Perspectives.
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