{"title":"Current status of the sterile insect technique for the suppression of mosquito populations on a global scale.","authors":"Jérémy Bouyer","doi":"10.1186/s40249-024-01242-z","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>The World Health Organization (WHO) has emphasized the urgent need for alternative strategies to chemical insecticides for controlling mosquito populations, particularly the invasive Aedes species, which are known vectors of arboviruses. Among these alternative approaches, the sterile insect technique (SIT) is experiencing rapid development, with numerous pilot trials being conducted worldwide.</p><p><strong>Main text: </strong>This review aims to elucidate the principles of SIT and highlight the significant recent advancements that have facilitated its scalability. I also employ a phased conditional approach to categorize the progression of 39 projects, drawing on peer reviewed studies, press releases and direct communication with project managers. This review indicates that a substantial number of projects illustrate the efficacy of SIT in suppressing Aedes populations, with one project even demonstrating a reduction in dengue incidence. I offer several recommendations to mitigate potential failures and address the challenges of compensation and overcompensation when implementing SIT field trials. Furthermore, I examine the potential implications of male mating harassment on the effectiveness of SIT in reducing disease transmission.</p><p><strong>Conclusions: </strong>This comprehensive assessment underscores the promise of SIT as a viable strategy for mosquito control. The insights gained from these trials not only contribute to the understanding of SIT's effectiveness but also highlight the importance of careful project management and ecological considerations in the pursuit of public health objectives.</p>","PeriodicalId":48820,"journal":{"name":"Infectious Diseases of Poverty","volume":null,"pages":null},"PeriodicalIF":8.1000,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11426227/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Infectious Diseases of Poverty","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s40249-024-01242-z","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Background: The World Health Organization (WHO) has emphasized the urgent need for alternative strategies to chemical insecticides for controlling mosquito populations, particularly the invasive Aedes species, which are known vectors of arboviruses. Among these alternative approaches, the sterile insect technique (SIT) is experiencing rapid development, with numerous pilot trials being conducted worldwide.
Main text: This review aims to elucidate the principles of SIT and highlight the significant recent advancements that have facilitated its scalability. I also employ a phased conditional approach to categorize the progression of 39 projects, drawing on peer reviewed studies, press releases and direct communication with project managers. This review indicates that a substantial number of projects illustrate the efficacy of SIT in suppressing Aedes populations, with one project even demonstrating a reduction in dengue incidence. I offer several recommendations to mitigate potential failures and address the challenges of compensation and overcompensation when implementing SIT field trials. Furthermore, I examine the potential implications of male mating harassment on the effectiveness of SIT in reducing disease transmission.
Conclusions: This comprehensive assessment underscores the promise of SIT as a viable strategy for mosquito control. The insights gained from these trials not only contribute to the understanding of SIT's effectiveness but also highlight the importance of careful project management and ecological considerations in the pursuit of public health objectives.
背景:世界卫生组织(WHO)强调,迫切需要采取替代化学杀虫剂的策略来控制蚊子数量,特别是已知为虫媒病毒传播媒介的入侵伊蚊。在这些替代方法中,昆虫不育技术(SIT)发展迅速,目前正在世界各地进行大量试点试验:这篇综述旨在阐明昆虫不育技术的原理,并重点介绍近期促进其可扩展性的重大进展。我还采用了一种分阶段的条件方法,对 39 个项目的进展情况进行了分类,并参考了同行评审的研究报告、新闻稿以及与项目经理的直接交流。审查结果表明,大量项目证明了 SIT 在抑制伊蚊种群方面的功效,其中一个项目甚至证明了登革热发病率的下降。我提出了几项建议,以减少潜在的失败,并应对在实施 SIT 实地试验时补偿和过度补偿的挑战。此外,我还研究了雄性交配骚扰对 SIT 减少疾病传播效果的潜在影响:这项全面的评估强调了 SIT 作为一种可行的蚊虫控制策略的前景。从这些试验中获得的启示不仅有助于人们了解 SIT 的有效性,而且还强调了在实现公共卫生目标的过程中进行谨慎的项目管理和生态考虑的重要性。
期刊介绍:
Infectious Diseases of Poverty is an open access, peer-reviewed journal that focuses on addressing essential public health questions related to infectious diseases of poverty. The journal covers a wide range of topics including the biology of pathogens and vectors, diagnosis and detection, treatment and case management, epidemiology and modeling, zoonotic hosts and animal reservoirs, control strategies and implementation, new technologies and application. It also considers the transdisciplinary or multisectoral effects on health systems, ecohealth, environmental management, and innovative technology. The journal aims to identify and assess research and information gaps that hinder progress towards new interventions for public health problems in the developing world. Additionally, it provides a platform for discussing these issues to advance research and evidence building for improved public health interventions in poor settings.