{"title":"Reading the m<sup>6</sup>A-encoded epitranscriptomic information in development and diseases.","authors":"Yunbing Chen, Ziyu Zhou, Yanxi Chen, Di Chen","doi":"10.1186/s13578-024-01293-7","DOIUrl":null,"url":null,"abstract":"<p><p>N<sup>6</sup>-methyladenosine (m<sup>6</sup>A) represents the most prevalent internal and reversible modification on RNAs. Different cell types display their unique m<sup>6</sup>A profiles, which are determined by the functions of m<sup>6</sup>A writers and erasers. M<sup>6</sup>A modifications lead to different outcomes such as decay, stabilization, or transport of the RNAs. The m<sup>6</sup>A-encoded epigenetic information is interpreted by m<sup>6</sup>A readers and their interacting proteins. M<sup>6</sup>A readers are essential for different biological processes, and the defects in m<sup>6</sup>A readers have been discovered in diverse diseases. Here, we review the latest advances in the roles of m<sup>6</sup>A readers in development and diseases. These recent studies not only highlight the importance of m<sup>6</sup>A readers in regulating cell fate transitions, but also point to the potential application of drugs targeting m<sup>6</sup>A readers in diseases.</p>","PeriodicalId":49095,"journal":{"name":"Cell and Bioscience","volume":"14 1","pages":"124"},"PeriodicalIF":6.1000,"publicationDate":"2024-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11439334/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cell and Bioscience","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1186/s13578-024-01293-7","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
N6-methyladenosine (m6A) represents the most prevalent internal and reversible modification on RNAs. Different cell types display their unique m6A profiles, which are determined by the functions of m6A writers and erasers. M6A modifications lead to different outcomes such as decay, stabilization, or transport of the RNAs. The m6A-encoded epigenetic information is interpreted by m6A readers and their interacting proteins. M6A readers are essential for different biological processes, and the defects in m6A readers have been discovered in diverse diseases. Here, we review the latest advances in the roles of m6A readers in development and diseases. These recent studies not only highlight the importance of m6A readers in regulating cell fate transitions, but also point to the potential application of drugs targeting m6A readers in diseases.
期刊介绍：
Cell and Bioscience, the official journal of the Society of Chinese Bioscientists in America, is an open access, peer-reviewed journal that encompasses all areas of life science research.
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