Reduced pineal gland volume in patients with obsessive-compulsive disorder.

IF 1.1 4区医学 Q4 PSYCHIATRY International Journal of Psychiatry in Medicine Pub Date : 2024-09-24 DOI:10.1177/00912174241287996

Murad Atmaca, Sevler Yildiz, Muhammed Fatih Tabara, Mehmet Gurkan Gurok, Mustafa Yildirim, Hanefi Yildirim

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Abstract

Objective: Patients with obsessive-compulsive disorder (OCD) can have hyperactivity of the hypothalamic-pituitary-adrenal axis and may have increased secretion of adrenocorticotropic hormone and cortisol and reduced secretion of melatonin. Examination of pineal gland volumes in patients with OCD compared to healthy controls, thus, is an important consideration and the focus of this study.

Methods: A total of 20 patients with OCD and 20 healthy controls were enrolled. Demographic and clinical characteristics of participants were assessed, and structural magnetic resonance imaging was performed.

Results: Patients with OCD had a statistically significant smaller pineal gland volumes compared to healthy controls.

Conclusion: In this initial small study, patients with OCD exhibited smaller pineal gland volumes compared to healthy control subjects. While this finding suggests a potential link between the pineal gland and OCD pathophysiology, further research with larger sample sizes and measurement of hormonal changes are necessary.

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强迫症患者松果体体积减少。

目的：强迫症（OCD）患者会出现下丘脑-垂体-肾上腺轴功能亢进，促肾上腺皮质激素和皮质醇分泌增加，褪黑激素分泌减少。因此，与健康对照组相比，检查强迫症患者松果体的体积是一个重要的考虑因素，也是本研究的重点：方法：共招募了 20 名强迫症患者和 20 名健康对照者。方法：共招募了 20 名强迫症患者和 20 名健康对照者，评估了参与者的人口统计学和临床特征，并进行了结构磁共振成像检查：结果：与健康对照组相比，强迫症患者的松果体体积明显较小：在这项初步的小型研究中，与健康对照组相比，强迫症患者的松果体体积较小。虽然这一发现表明松果体与强迫症病理生理学之间存在潜在联系，但仍有必要进行样本量更大的进一步研究，并对荷尔蒙变化进行测量。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Psychiatry in Medicine 医学-精神病学

CiteScore

3.00

自引率

5.00%

发文量

审稿时长

6-12 weeks

期刊介绍： The International Journal of Psychiatry in Medicine (IJPM) bridges the gap between clinical psychiatry research and primary care clinical research. Providing a forum for addressing: The relevance of psychobiological, psychological, social, familial, religious, and cultural factors in the development and treatment of illness; the relationship of biomarkers to psychiatric symptoms and syndromes in primary care...